TY - JOUR
T1 - Genetic susceptibility to Graves' ophthalmopathy
T2 - The role of polymorphisms in anti-inflammatory cytokine genes
AU - Khalilzadeh, Omid
AU - Anvari, Mehdi
AU - Esteghamati, Alireza
AU - Momen-Heravi, Fatemeh
AU - Rashidi, Armin
AU - Amiri, Hoda Mojazi
AU - Tahvildari, Maryam
AU - Mahmoudi, Mahdi
AU - Amirzargar, Aliakbar
N1 - Funding Information:
This study is supported financially by a grant from Tehran University of Medical Sciences, Tehran, Iran.
Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2010/12
Y1 - 2010/12
N2 - Background: Various polymorphisms occur in cytokine genes involved in inflammatory processes in Graves' ophthalmopathy (GO). Anti-inflammatory cytokines such as transforming growth factor- β (TGF-β), interleukin-10 (IL-10) and interleukin-4 (IL-4) are among those believed to be involved in the disease process. In this study, we investigated the association between 8 polymorphisms within the mentioned cytokines and GO. Methods: The following polymorphisms were studied in 50 patients with GO, 57 Graves' patients without GO and 140 healthy individuals using polymerase chain reaction with sequence-specific primers: TGF-β (869C/T, 915G/C), IL-10 (-1082A/G, -819C/T, -592C/A) and IL-4 (-1098T/G, -590T/C, -33C/T). A corrected p value less than 0.05 was considered statistically significant. Results: The TGF-β 915C allele (Odds Ratio [OR]2.20) and CC genotype (OR7.50) as well as 869C allele (OR2.21) showed significant correlations with GO. Regarding IL-4 polymorphisms, the -1098G allele (OR2.09) and GG genotype (OR7.49), and the -33T allele (OR2.05) and TT genotype (OR4.00) were significantly associated with GO. The IL-10 -819TT genotype (OR5.00) was significantly correlated with GO. Conclusion: This is the first study to show that polymorphisms in anti-inflammatory cytokine genes are associated with susceptibility to GO.
AB - Background: Various polymorphisms occur in cytokine genes involved in inflammatory processes in Graves' ophthalmopathy (GO). Anti-inflammatory cytokines such as transforming growth factor- β (TGF-β), interleukin-10 (IL-10) and interleukin-4 (IL-4) are among those believed to be involved in the disease process. In this study, we investigated the association between 8 polymorphisms within the mentioned cytokines and GO. Methods: The following polymorphisms were studied in 50 patients with GO, 57 Graves' patients without GO and 140 healthy individuals using polymerase chain reaction with sequence-specific primers: TGF-β (869C/T, 915G/C), IL-10 (-1082A/G, -819C/T, -592C/A) and IL-4 (-1098T/G, -590T/C, -33C/T). A corrected p value less than 0.05 was considered statistically significant. Results: The TGF-β 915C allele (Odds Ratio [OR]2.20) and CC genotype (OR7.50) as well as 869C allele (OR2.21) showed significant correlations with GO. Regarding IL-4 polymorphisms, the -1098G allele (OR2.09) and GG genotype (OR7.49), and the -33T allele (OR2.05) and TT genotype (OR4.00) were significantly associated with GO. The IL-10 -819TT genotype (OR5.00) was significantly correlated with GO. Conclusion: This is the first study to show that polymorphisms in anti-inflammatory cytokine genes are associated with susceptibility to GO.
KW - IL-4
KW - TGF-β; IL-10
KW - graves' ophthalmopathy
KW - polymorphism
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U2 - 10.3109/13816810.2010.515648
DO - 10.3109/13816810.2010.515648
M3 - Article
C2 - 21067483
AN - SCOPUS:78649307747
SN - 1381-6810
VL - 31
SP - 215
EP - 220
JO - Ophthalmic Genetics
JF - Ophthalmic Genetics
IS - 4
ER -