Abstract
Genetic redundancy stems from the observation that biological systems are often surprisingly robust to genetic perturbations. Even in the extreme case of gene deletion mutants, it appears that a minority of genes are necessary for normal cellular function. Understanding genetic redundancy is important for understanding the theory of evolution and its exact nature has been a highly debated topic. Experimental observation of genetic redundancy is itself a useful tool for discovery in biological systems.
| Original language | English (US) |
|---|---|
| Title of host publication | Brenner's Encyclopedia of Genetics |
| Subtitle of host publication | Second Edition |
| Publisher | Elsevier Inc. |
| Pages | 281-283 |
| Number of pages | 3 |
| ISBN (Electronic) | 9780080961569 |
| ISBN (Print) | 9780123749840 |
| DOIs | |
| State | Published - Feb 27 2013 |
Bibliographical note
Publisher Copyright:© 2013 Elsevier Inc. All rights reserved.
Keywords
- Biological robustness
- Duplicate genes
- Epistasis
- Genetic interaction
- Genetic robustness
- Paralogous genes
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