Genetic Redundancy

J. Bellay; Chad L Myers

doi:10.1016/B978-0-12-374984-0.00628-8

Genetic Redundancy

J. Bellay, Chad L Myers

Computer Science and Engineering

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Genetic redundancy stems from the observation that biological systems are often surprisingly robust to genetic perturbations. Even in the extreme case of gene deletion mutants, it appears that a minority of genes are necessary for normal cellular function. Understanding genetic redundancy is important for understanding the theory of evolution and its exact nature has been a highly debated topic. Experimental observation of genetic redundancy is itself a useful tool for discovery in biological systems.

Original language	English (US)
Title of host publication	Brenner's Encyclopedia of Genetics
Subtitle of host publication	Second Edition
Publisher	Elsevier Inc.
Pages	281-283
Number of pages	3
ISBN (Electronic)	9780080961569
ISBN (Print)	9780123749840
DOIs	https://doi.org/10.1016/B978-0-12-374984-0.00628-8
State	Published - Feb 27 2013

Keywords

Biological robustness
Duplicate genes
Epistasis
Genetic interaction
Genetic robustness
Paralogous genes

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10.1016/B978-0-12-374984-0.00628-8

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AU - Myers, Chad L

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AB - Genetic redundancy stems from the observation that biological systems are often surprisingly robust to genetic perturbations. Even in the extreme case of gene deletion mutants, it appears that a minority of genes are necessary for normal cellular function. Understanding genetic redundancy is important for understanding the theory of evolution and its exact nature has been a highly debated topic. Experimental observation of genetic redundancy is itself a useful tool for discovery in biological systems.

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KW - Duplicate genes

KW - Epistasis

KW - Genetic interaction

KW - Genetic robustness

KW - Paralogous genes

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BT - Brenner's Encyclopedia of Genetics

PB - Elsevier Inc.

ER -

Genetic Redundancy

Abstract

Keywords

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