Genetic Redundancy

J. Bellay, Chad L Myers

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Genetic redundancy stems from the observation that biological systems are often surprisingly robust to genetic perturbations. Even in the extreme case of gene deletion mutants, it appears that a minority of genes are necessary for normal cellular function. Understanding genetic redundancy is important for understanding the theory of evolution and its exact nature has been a highly debated topic. Experimental observation of genetic redundancy is itself a useful tool for discovery in biological systems.

Original languageEnglish (US)
Title of host publicationBrenner's Encyclopedia of Genetics
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Pages281-283
Number of pages3
ISBN (Electronic)9780080961569
ISBN (Print)9780123749840
DOIs
StatePublished - Feb 27 2013

Keywords

  • Biological robustness
  • Duplicate genes
  • Epistasis
  • Genetic interaction
  • Genetic robustness
  • Paralogous genes

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