Genetic mapping of Ir locus in man: Linkage to second locus of HL-A

M. N. Blumenthal; D. B. Amos; H. Noreen; N. R. Mendell; E. J. Yunis

doi:10.1126/science.184.4143.1301

Genetic mapping of Ir locus in man: Linkage to second locus of HL-A

M. N. Blumenthal, D. B. Amos, H. Noreen, N. R. Mendell, E. J. Yunis

Pulmonary, Allergy, Critical Care and Sleep Medicine

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Abstract

Fifty-seven members of a family that spanned three generations were studied for antigen E and ragweed skin sensitivity and HL-A antigens. There was significant association between the haplotype HL-A 2-12 and antigen E skin hypersensitivity (F = .22 to .26) in this family. The map order is first locus of HL-A, second locus of HL-A, and IrE. These determinants are considered to be part of the linkage group HL-1.

Original language	English (US)
Pages (from-to)	1301-1303
Number of pages	3
Journal	Science
Volume	184
Issue number	4143
DOIs	https://doi.org/10.1126/science.184.4143.1301
State	Published - 1974

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abstract = "Fifty-seven members of a family that spanned three generations were studied for antigen E and ragweed skin sensitivity and HL-A antigens. There was significant association between the haplotype HL-A 2-12 and antigen E skin hypersensitivity (F = .22 to .26) in this family. The map order is first locus of HL-A, second locus of HL-A, and IrE. These determinants are considered to be part of the linkage group HL-1.",

author = "Blumenthal, {M. N.} and Amos, {D. B.} and H. Noreen and Mendell, {N. R.} and Yunis, {E. J.}",

year = "1974",

doi = "10.1126/science.184.4143.1301",

language = "English (US)",

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T1 - Genetic mapping of Ir locus in man

T2 - Linkage to second locus of HL-A

AU - Blumenthal, M. N.

AU - Amos, D. B.

AU - Noreen, H.

AU - Mendell, N. R.

AU - Yunis, E. J.

PY - 1974

Y1 - 1974

N2 - Fifty-seven members of a family that spanned three generations were studied for antigen E and ragweed skin sensitivity and HL-A antigens. There was significant association between the haplotype HL-A 2-12 and antigen E skin hypersensitivity (F = .22 to .26) in this family. The map order is first locus of HL-A, second locus of HL-A, and IrE. These determinants are considered to be part of the linkage group HL-1.

AB - Fifty-seven members of a family that spanned three generations were studied for antigen E and ragweed skin sensitivity and HL-A antigens. There was significant association between the haplotype HL-A 2-12 and antigen E skin hypersensitivity (F = .22 to .26) in this family. The map order is first locus of HL-A, second locus of HL-A, and IrE. These determinants are considered to be part of the linkage group HL-1.

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JO - Science

JF - Science

IS - 4143

ER -

Genetic mapping of Ir locus in man: Linkage to second locus of HL-A

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