Genetic mapping of Ir locus in man: Linkage to second locus of HL-A

M. N. Blumenthal, D. B. Amos, H. Noreen, N. R. Mendell, E. J. Yunis

Research output: Contribution to journalArticlepeer-review

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Abstract

Fifty-seven members of a family that spanned three generations were studied for antigen E and ragweed skin sensitivity and HL-A antigens. There was significant association between the haplotype HL-A 2-12 and antigen E skin hypersensitivity (F = .22 to .26) in this family. The map order is first locus of HL-A, second locus of HL-A, and IrE. These determinants are considered to be part of the linkage group HL-1.

Original languageEnglish (US)
Pages (from-to)1301-1303
Number of pages3
JournalScience
Volume184
Issue number4143
DOIs
StatePublished - Jan 1 1974

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