Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome 14

Gerard D. Schellenberg, Thomas D. Bird, Ellen M. Wijsman, Harry T. Orr, Leojean Anderson, Ellen Nemens, June A. White, Lori Bonnycastle, James L. Weber, M. Elisa Alonso, Huntington Potter, Leonard L. Heston, George M. Martin

Research output: Contribution to journalArticlepeer-review

750 Scopus citations

Abstract

Linkage analysis was used to search the genome for chromosomal regions harboring familial Alzheimer's disease genes. Markers on chromosome 14 gave highly significant positive lod scores in early-onset non-Volga German kindreds; a Zmax of 9.15 (θ=0.01) was obtained with the marker D14S43 at 14q24.3. One early-onset family yielded a lod score of 4.89 (θ=0.0). When no assumptions were made about age-dependent penetrance, significant results were still obtained (Zmax=5.94, θ=0.0), despite the loss of power to detect linkage under these conditions. Results for the Volga German families were either negative or nonsignificant for markers in this region. Thus, evidence indicates a familial Alzheimer's disease locus on chromosome 14.

Original languageEnglish (US)
Pages (from-to)668-671
Number of pages4
JournalScience
Volume258
Issue number5082
DOIs
StatePublished - 1992

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