Genetic heterogeneity and localization of a familial breast-ovarian cancer gene on chromosome 17q12-q21

S. A. Smith, D. F. Easton, D. Ford, J. Peto, K. Anderson, D. Averill, M. Stratton, M. Ponder, C. Pye, B. A J Ponder

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

In a study of 31 breast cancer families and 12 breast-ovarian cancer families, we have obtained clear evidence of linkage to markers on chromosome 17q in the families with ovarian cancer (maximum lod score 3.34 at θ = .04) but only weak evidence in those without ovarian cancer. Recombinant events indicate that the gene lies between D17S588 and D17S250.

Original languageEnglish (US)
Pages (from-to)767-776
Number of pages10
JournalAmerican Journal of Human Genetics
Volume52
Issue number4
StatePublished - Jan 1 1993

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