In a study of 31 breast cancer families and 12 breast-ovarian cancer families, we have obtained clear evidence of linkage to markers on chromosome 17q in the families with ovarian cancer (maximum lod score 3.34 at θ = .04) but only weak evidence in those without ovarian cancer. Recombinant events indicate that the gene lies between D17S588 and D17S250.
|Original language||English (US)|
|Number of pages||10|
|Journal||American Journal of Human Genetics|
|State||Published - Jan 1 1993|