Genetic Engineering of Oncolytic Viruses for Cancer Therapy

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

This chapter will review the recent clinical application of therapeutic viruses for the treatment of cancer. While certain viruses have been known to have the ability to kill cancer cells, it is only from 1990 to 2010 that technological advances in viral culture methodology and molecular engineering have made clinical translation possible. Many different viruses are in clinical testing currently, and several are being tested in advanced efficacy trials. While these agents have been abundantly safe, there has been mixed efficacy seen and somewhat more modest results than expected when compared to preclinical models. Therefore, this chapter aims to review the current status of oncolytic viruses and the molecular approaches that are being utilized to improve upon the platform of oncolytic virotherapy for clinical translation.

Original languageEnglish (US)
Title of host publicationTranslating Gene Therapy to the Clinic
Subtitle of host publicationTechniques and Approaches
PublisherElsevier Inc.
Pages261-279
Number of pages19
ISBN (Electronic)9780128005644
ISBN (Print)9780128005637
DOIs
StatePublished - Nov 17 2014

Fingerprint

Oncolytic Virotherapy
Genetic engineering
Genetic Engineering
Viruses
Oncolytic Viruses
Neoplasms
Cells
Therapeutics
Testing

Keywords

  • Adenovirus
  • Adoptive immunotherapy
  • Cytokines
  • Measles
  • Oncolytic

Cite this

Patel, M. R., & Kratzke, R. A. (2014). Genetic Engineering of Oncolytic Viruses for Cancer Therapy. In Translating Gene Therapy to the Clinic: Techniques and Approaches (pp. 261-279). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-800563-7.00017-8

Genetic Engineering of Oncolytic Viruses for Cancer Therapy. / Patel, Manish R; Kratzke, Robert A.

Translating Gene Therapy to the Clinic: Techniques and Approaches. Elsevier Inc., 2014. p. 261-279.

Research output: Chapter in Book/Report/Conference proceedingChapter

Patel, MR & Kratzke, RA 2014, Genetic Engineering of Oncolytic Viruses for Cancer Therapy. in Translating Gene Therapy to the Clinic: Techniques and Approaches. Elsevier Inc., pp. 261-279. https://doi.org/10.1016/B978-0-12-800563-7.00017-8
Patel MR, Kratzke RA. Genetic Engineering of Oncolytic Viruses for Cancer Therapy. In Translating Gene Therapy to the Clinic: Techniques and Approaches. Elsevier Inc. 2014. p. 261-279 https://doi.org/10.1016/B978-0-12-800563-7.00017-8
Patel, Manish R ; Kratzke, Robert A. / Genetic Engineering of Oncolytic Viruses for Cancer Therapy. Translating Gene Therapy to the Clinic: Techniques and Approaches. Elsevier Inc., 2014. pp. 261-279
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