Genetic engineering of dendritic cells to express immunosuppressive molecules (viral IL-10, TGF-β, and CTLA4Ig)

Lina Lu, Wei Chen Lee, Takuya Takayama, Shiguang Qian, Andrea Gambotto, Paul D. Robbins, Angus W. Thomson

Research output: Contribution to journalArticlepeer-review

75 Scopus citations

Abstract

There is growing evidence that, in addition to their role as initiators of immune responses, dendritic cells (DC) can exhibit tolerogenic properties. Immature DC deficient in cell surface costimulatory/accessory molecules can prolong organ and pancreatic islet allograft survival, whereas in vitro manipulation of DC by exposure to a variety of factors (e.g., viral interleukin-10; CTLA4Ig) can confer tolerogenic properties on these cells. Genetic engineering of DC to express immunosuppressive molecules is, in theory, an attractive approach to the therapy of allograft rejection and possibly, autoimmune disorders.

Original languageEnglish (US)
Pages (from-to)293-296
Number of pages4
JournalJournal of Leukocyte Biology
Volume66
Issue number2
DOIs
StatePublished - 1999
Externally publishedYes

Keywords

  • Gene therapy
  • Immunosuppression

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