TY - JOUR
T1 - Genetic Design via Combinatorial Constraint Specification
AU - Bhatia, Swapnil P.
AU - Smanski, Michael J.
AU - Voigt, Christopher A.
AU - Densmore, Douglas M.
N1 - Publisher Copyright:
© 2017 American Chemical Society.
PY - 2017/11/17
Y1 - 2017/11/17
N2 - We present a formal language for specifying via constraints a "design space" of DNA constructs composed of genetic parts, and an algorithm for automatically and correctly creating a novel representation of the space of satisfying designs. The language is simple, captures a large class of design spaces, and possesses algorithms for common operations on design spaces. The flexibility of this approach is demonstrated using a 16-gene nitrogen fixation pathway and genetic logic circuits.
AB - We present a formal language for specifying via constraints a "design space" of DNA constructs composed of genetic parts, and an algorithm for automatically and correctly creating a novel representation of the space of satisfying designs. The language is simple, captures a large class of design spaces, and possesses algorithms for common operations on design spaces. The flexibility of this approach is demonstrated using a 16-gene nitrogen fixation pathway and genetic logic circuits.
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U2 - 10.1021/acssynbio.7b00154
DO - 10.1021/acssynbio.7b00154
M3 - Article
C2 - 28874044
AN - SCOPUS:85034568525
SN - 2161-5063
VL - 6
SP - 2130
EP - 2135
JO - ACS Synthetic Biology
JF - ACS Synthetic Biology
IS - 11
ER -