TY - JOUR
T1 - Genetic and environmental modulation of neurodevelopmental disorders
T2 - Translational insights from labs to beds
AU - Homberg, Judith R.
AU - Kyzar, Evan J.
AU - Scattoni, Maria Luisa
AU - Norton, William H.
AU - Pittman, Julian
AU - Gaikwad, Siddharth
AU - Nguyen, Michael
AU - Poudel, Manoj K.
AU - Ullmann, Jeremy F P
AU - Diamond, David M.
AU - Kaluyeva, Aleksandra A.
AU - Parker, Matthew O.
AU - Brown, Richard E.
AU - Song, Cai
AU - Gainetdinov, Raul R.
AU - Gottesman, Irving I.
AU - Kalueff, Allan V.
N1 - Publisher Copyright:
© 2016 Elsevier Inc.
PY - 2016/7/1
Y1 - 2016/7/1
N2 - Neurodevelopmental disorders (NDDs) are a heterogeneous group of prevalent neuropsychiatric illnesses with various degrees of social, cognitive, motor, language and affective deficits. NDDs are caused by aberrant brain development due to genetic and environmental perturbations. Common NDDs include autism spectrum disorder (ASD), intellectual disability, communication/speech disorders, motor/tic disorders and attention deficit hyperactivity disorder. Genetic and epigenetic/environmental factors play a key role in these NDDs with significant societal impact. Given the lack of their efficient therapies, it is important to gain further translational insights into the pathobiology of NDDs. To address these challenges, the International Stress and Behavior Society (ISBS) has established the Strategic Task Force on NDDs. Summarizing the Panel's findings, here we discuss the neurobiological mechanisms of selected common NDDs and a wider NDD+ spectrum of associated neuropsychiatric disorders with developmental trajectories. We also outline the utility of existing preclinical (animal) models for building translational and cross-diagnostic bridges to improve our understanding of various NDDs.
AB - Neurodevelopmental disorders (NDDs) are a heterogeneous group of prevalent neuropsychiatric illnesses with various degrees of social, cognitive, motor, language and affective deficits. NDDs are caused by aberrant brain development due to genetic and environmental perturbations. Common NDDs include autism spectrum disorder (ASD), intellectual disability, communication/speech disorders, motor/tic disorders and attention deficit hyperactivity disorder. Genetic and epigenetic/environmental factors play a key role in these NDDs with significant societal impact. Given the lack of their efficient therapies, it is important to gain further translational insights into the pathobiology of NDDs. To address these challenges, the International Stress and Behavior Society (ISBS) has established the Strategic Task Force on NDDs. Summarizing the Panel's findings, here we discuss the neurobiological mechanisms of selected common NDDs and a wider NDD+ spectrum of associated neuropsychiatric disorders with developmental trajectories. We also outline the utility of existing preclinical (animal) models for building translational and cross-diagnostic bridges to improve our understanding of various NDDs.
KW - Experimental model
KW - Model organism
KW - Neurodevelopmental disorder
KW - Preclinical study
KW - Translational research
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U2 - 10.1016/j.brainresbull.2016.04.015
DO - 10.1016/j.brainresbull.2016.04.015
M3 - Review article
C2 - 27113433
AN - SCOPUS:84964555219
SN - 0361-9230
VL - 125
SP - 79
EP - 91
JO - Brain Research Bulletin
JF - Brain Research Bulletin
ER -