Genetic and environmental modulation of neurodevelopmental disorders: Translational insights from labs to beds

Judith R. Homberg, Evan J. Kyzar, Maria Luisa Scattoni, William H. Norton, Julian Pittman, Siddharth Gaikwad, Michael Nguyen, Manoj K. Poudel, Jeremy F P Ullmann, David M. Diamond, Aleksandra A. Kaluyeva, Matthew O. Parker, Richard E. Brown, Cai Song, Raul R. Gainetdinov, Irving I. Gottesman, Allan V. Kalueff

Research output: Contribution to journalReview articlepeer-review

27 Scopus citations

Abstract

Neurodevelopmental disorders (NDDs) are a heterogeneous group of prevalent neuropsychiatric illnesses with various degrees of social, cognitive, motor, language and affective deficits. NDDs are caused by aberrant brain development due to genetic and environmental perturbations. Common NDDs include autism spectrum disorder (ASD), intellectual disability, communication/speech disorders, motor/tic disorders and attention deficit hyperactivity disorder. Genetic and epigenetic/environmental factors play a key role in these NDDs with significant societal impact. Given the lack of their efficient therapies, it is important to gain further translational insights into the pathobiology of NDDs. To address these challenges, the International Stress and Behavior Society (ISBS) has established the Strategic Task Force on NDDs. Summarizing the Panel's findings, here we discuss the neurobiological mechanisms of selected common NDDs and a wider NDD+ spectrum of associated neuropsychiatric disorders with developmental trajectories. We also outline the utility of existing preclinical (animal) models for building translational and cross-diagnostic bridges to improve our understanding of various NDDs.

Original languageEnglish (US)
Pages (from-to)79-91
Number of pages13
JournalBrain Research Bulletin
Volume125
DOIs
StatePublished - Jul 1 2016

Bibliographical note

Funding Information:
This study was coordinated by the International Stress and Behavior Society (ISBS) Task Force on Neurodevelopmental Disorders, chaired by Prof. Allan V. Kalueff, ISBS President. MKP is a Nepalistani Fellow. This research is supported by Guangdong Ocean University (CS) , ZENEREI Research Center, St. Petersburg State University funding to AVK , and the Russian Science Foundation grant N14-15-00131 (RRG).

Keywords

  • Experimental model
  • Model organism
  • Neurodevelopmental disorder
  • Preclinical study
  • Translational research

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