Genetic and environmental links between cognitive and physical functions in old age

Wendy Johnson, Ian J. Deary, Matt McGue, Kaare Christensen

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

In old age, cognitive and physical functions are correlated. Knowing the correlations between genetic and environmental influences underlying this correlation can help to clarify the reasons for the observable (phenotypic) correlation. We estimated these correlations in a sample of 1,053 pairs of twins from the Longitudinal Study of Aging Danish Twins. Cognitive function was measured using forward and backward digit span, immediate and delayed memory, and fluency tasks. Physical function was measured using self-report of ability to carry out physical activities including walking, running, and climbing stairs. The phenotypic correlation between latent variable representations was .46 (95% confidence interval 0.27-0.65). The genetic correlation was .56 (95% confidence interval 0.15-1.00) and the nonshared environmental correlation .48 (95% confidence interval 0.35-0.61). We discuss several ways of interpreting these correlations.

Original languageEnglish (US)
Pages (from-to)65-72
Number of pages8
JournalJournals of Gerontology - Series B Psychological Sciences and Social Sciences
Volume64
Issue number1
DOIs
StatePublished - Jan 2009

Bibliographical note

Funding Information:
The LSADT was supported by grants from the U.S. National Institute on Aging (PO1-AG08761) and the Danish National Research Foundation. I.J.D. is the recipient of a Royal Society Wolfson Research Merit Award. W.J. holds a Research Council UK Fellowship. The Danish Aging Research Center is supported by a grant from the VELUX foundation.

Keywords

  • Genetic and environmental correlation
  • Late-life cognitive ability
  • Physical fitness

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