Genetic and environmental determinants of level of pulmonary function

F. I. Lewiiter, I. B. Tager, M. Mcgue, P. V. Tishler, F. E. Speizer

Research output: Contribution to journalArticlepeer-review

71 Scopus citations

Abstract

Measurements of level of pulmonary function (one second forced expiratory volume (FEV1) and forced expiratory flow between the 25% and 75% volume points (FEF25-75) were obtained on members of 404 nuclear families living in East Boston, Massachusetts In 1974. These families were ascertained through a random sample of children aged 5-9 years. Measurements were obtained on family members on three separate occasions during a 5-year period. These data were subjected to the techniques of path analysts to study the relative contributions of heredity and environment to individual levels of pulmonary function. Genetic heritability was found to be consistent through time (41-47%) and was the same for parents and their children. Common familial environmental effects on levei of pulmonary function explained 1-4% of the variability in children and 11-28% in adults. Furthermore, we were able to confirm prior epidemiologic analysis of these data which have demonstrated an effect of maternal smoking on the level of pulmonary function in their children.

Original languageEnglish (US)
Pages (from-to)518-530
Number of pages13
JournalAmerican journal of epidemiology
Volume120
Issue number4
DOIs
StatePublished - Oct 1984

Keywords

  • Family characteristics
  • Genetics
  • Respiratory function test

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