TY - JOUR
T1 - Genetic analysis of integrin activation in T lymphocytes
AU - Kellermann, Sirid Aimée
AU - Dell, Cheryl L.
AU - Hunt, Stephen W.
AU - Shimizu, Yoji
PY - 2002/8
Y1 - 2002/8
N2 - Among the myriad receptors expressed by T cells, the sine qua non is the CD3/T cell receptor (CD3/TCR) complex, because it is uniquely capable of translating the presence of a specific antigen into intracellular signals necessary to trigger an immune response against a pathogen or tumor. Much work over the past 2 decades has attempted to define the signaling pathways leading from the CD3/TCR complex that culminate ultimately in the functions necessary for effective T cell immune responses, such as cytokine production. Here, we summarize recent advances in our understanding of the mechanisms by which the CD3/TCR complex controls integrin-mediated T cell adhesion, and discuss new information that suggests that there may be unexpected facets to this pathway that distinguish it from those previously defined.
AB - Among the myriad receptors expressed by T cells, the sine qua non is the CD3/T cell receptor (CD3/TCR) complex, because it is uniquely capable of translating the presence of a specific antigen into intracellular signals necessary to trigger an immune response against a pathogen or tumor. Much work over the past 2 decades has attempted to define the signaling pathways leading from the CD3/TCR complex that culminate ultimately in the functions necessary for effective T cell immune responses, such as cytokine production. Here, we summarize recent advances in our understanding of the mechanisms by which the CD3/TCR complex controls integrin-mediated T cell adhesion, and discuss new information that suggests that there may be unexpected facets to this pathway that distinguish it from those previously defined.
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U2 - 10.1034/j.1600-065X.2002.18615.x
DO - 10.1034/j.1600-065X.2002.18615.x
M3 - Review article
C2 - 12234371
AN - SCOPUS:0036696167
VL - 186
SP - 172
EP - 188
JO - Immunological Reviews
JF - Immunological Reviews
SN - 0105-2896
ER -