Abstract
Among the myriad receptors expressed by T cells, the sine qua non is the CD3/T cell receptor (CD3/TCR) complex, because it is uniquely capable of translating the presence of a specific antigen into intracellular signals necessary to trigger an immune response against a pathogen or tumor. Much work over the past 2 decades has attempted to define the signaling pathways leading from the CD3/TCR complex that culminate ultimately in the functions necessary for effective T cell immune responses, such as cytokine production. Here, we summarize recent advances in our understanding of the mechanisms by which the CD3/TCR complex controls integrin-mediated T cell adhesion, and discuss new information that suggests that there may be unexpected facets to this pathway that distinguish it from those previously defined.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 172-188 |
| Number of pages | 17 |
| Journal | Immunological Reviews |
| Volume | 186 |
| DOIs | |
| State | Published - Aug 1 2002 |
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Genetic analysis of integrin activation in T lymphocytes. / Kellermann, Sirid Aimée; Dell, Cheryl L.; Hunt, Stephen W.; Shimizu, Yoji.
In: Immunological Reviews, Vol. 186, 01.08.2002, p. 172-188.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Genetic analysis of integrin activation in T lymphocytes
AU - Kellermann, Sirid Aimée
AU - Dell, Cheryl L.
AU - Hunt, Stephen W.
AU - Shimizu, Yoji
PY - 2002/8/1
Y1 - 2002/8/1
N2 - Among the myriad receptors expressed by T cells, the sine qua non is the CD3/T cell receptor (CD3/TCR) complex, because it is uniquely capable of translating the presence of a specific antigen into intracellular signals necessary to trigger an immune response against a pathogen or tumor. Much work over the past 2 decades has attempted to define the signaling pathways leading from the CD3/TCR complex that culminate ultimately in the functions necessary for effective T cell immune responses, such as cytokine production. Here, we summarize recent advances in our understanding of the mechanisms by which the CD3/TCR complex controls integrin-mediated T cell adhesion, and discuss new information that suggests that there may be unexpected facets to this pathway that distinguish it from those previously defined.
AB - Among the myriad receptors expressed by T cells, the sine qua non is the CD3/T cell receptor (CD3/TCR) complex, because it is uniquely capable of translating the presence of a specific antigen into intracellular signals necessary to trigger an immune response against a pathogen or tumor. Much work over the past 2 decades has attempted to define the signaling pathways leading from the CD3/TCR complex that culminate ultimately in the functions necessary for effective T cell immune responses, such as cytokine production. Here, we summarize recent advances in our understanding of the mechanisms by which the CD3/TCR complex controls integrin-mediated T cell adhesion, and discuss new information that suggests that there may be unexpected facets to this pathway that distinguish it from those previously defined.
UR - http://www.scopus.com/inward/record.url?scp=0036696167&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036696167&partnerID=8YFLogxK
U2 - 10.1034/j.1600-065X.2002.18615.x
DO - 10.1034/j.1600-065X.2002.18615.x
M3 - Review article
C2 - 12234371
AN - SCOPUS:0036696167
VL - 186
SP - 172
EP - 188
JO - Immunological Reviews
JF - Immunological Reviews
SN - 0105-2896
ER -