Genetic algorithm optimized triply compensated pulses in NMR spectroscopy

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Sensitivity and resolution in NMR experiments are affected by magnetic field inhomogeneities (of both external and RF), errors in pulse calibration, and offset effects due to finite length of RF pulses. To remedy these problems, built-in compensation mechanisms for these experimental imperfections are often necessary. Here, we propose a new family of phase-modulated constant-amplitude broadband pulses with high compensation for RF inhomogeneity and heteronuclear coupling evolution. These pulses were optimized using a genetic algorithm (GA), which consists in a global optimization method inspired by Nature's evolutionary processes. The newly designed π and π/2 pulses belong to the 'type A' (or general rotors) symmetric composite pulses. These GA-optimized pulses are relatively short compared to other general rotors and can be used for excitation and inversion, as well as refocusing pulses in spin-echo experiments. The performance of the GA-optimized pulses was assessed in Magic Angle Spinning (MAS) solid-state NMR experiments using a crystalline U-13C, 15N NAVL peptide as well as U-13C, 15N microcrystalline ubiquitin. GA optimization of NMR pulse sequences opens a window for improving current experiments and designing new robust pulse sequences.

Original languageEnglish (US)
Pages (from-to)136-143
Number of pages8
JournalJournal of Magnetic Resonance
StatePublished - Nov 1 2015

Bibliographical note

Publisher Copyright:
© 2015 Elsevier Inc. All rights reserved.


  • Composite pulses
  • Genetic algorithm
  • Pulse imperfections
  • RF inhomogeneity
  • Resonance offset
  • Triply compensated pulses
  • zz interactions


Dive into the research topics of 'Genetic algorithm optimized triply compensated pulses in NMR spectroscopy'. Together they form a unique fingerprint.

Cite this