Genes influencing Parkinson disease onset: Replication of PARK3 and identification of novel loci

N. Pankratz, S. K. Uniacke, C. A. Halter, A. Rudolph, C. W. Shults, P. M. Conneally, T. Foroud, W. C. Nichols

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

A genome screen to identify genes influencing the age at Parkinson disease (PD) onset was completed using 276 families without parkin mutations. Significant evidence of linkage to chromosome 2p near the PARK3 locus (logarithm of odds [lod] = 4.8) was observed. Evidence of linkage was also detected to chromosomes 1q (lod = 3.0) and 8q (lod = 2.6). These data suggest that the genes influencing age at PD onset likely differ from those that contribute to PD susceptibility.

Original languageEnglish (US)
Pages (from-to)1616-1618
Number of pages3
JournalNeurology
Volume62
Issue number9
DOIs
StatePublished - May 11 2004

Fingerprint Dive into the research topics of 'Genes influencing Parkinson disease onset: Replication of PARK3 and identification of novel loci'. Together they form a unique fingerprint.

  • Cite this

    Pankratz, N., Uniacke, S. K., Halter, C. A., Rudolph, A., Shults, C. W., Conneally, P. M., Foroud, T., & Nichols, W. C. (2004). Genes influencing Parkinson disease onset: Replication of PARK3 and identification of novel loci. Neurology, 62(9), 1616-1618. https://doi.org/10.1212/01.WNL.0000123112.51368.10