Genes for tumor markers are clustered with cellular proto-onvogenes on human chromosomes

John C. Hozier; Marc J. Mass; Jill M. Siegfried

doi:10.1016/0304-3835(87)90016-4

Genes for tumor markers are clustered with cellular proto-onvogenes on human chromosomes

John C. Hozier
, Marc J. Mass
, Jill M. Siegfried

Pharmacology

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Abstract

We have analyzed the relative mapping positions of genes for polypeptides expressed abnormally in tumors (tumor markers) and cellular proto-oncogenes and find a remarkable degree of co-mapping of tumor marker genes with oncogenes in the human karyotype. We propose that aberrant expression of marker genes in tumors may be related to their proximity in the human genome to oncogenes expresed during the development of malignancy, and we suggest ways to test this hypothesis of concerted abnormal gene expression in mammalian tumor cells.

Original language	English (US)
Pages (from-to)	235-245
Number of pages	11
Journal	Cancer Letters
Volume	36
Issue number	3
DOIs	https://doi.org/10.1016/0304-3835(87)90016-4
State	Published - Sep 1987

Bibliographical note

Funding Information:
For critical reading of manuscript we thank Drs. Richard A. Rubin, Marcia Applegate, J. Herbert Taylor and David G. Kaufman. We thank Ms. Debbie LaFrance for expert editorial assistance and Natalie de Vassal for help with the statistical analysis. This report has been reviewed by the Health Effects Research Laboratory, U.S. Environmental Protection Agency and approved for publication. This work was supported by U.S. Environmental Protection Agency contract No. 68-02-4032 (J.M.S.) and U.S. Environmental Protection Agency grant No. R811773 (J.C.H.).

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title = "Genes for tumor markers are clustered with cellular proto-onvogenes on human chromosomes",

abstract = "We have analyzed the relative mapping positions of genes for polypeptides expressed abnormally in tumors (tumor markers) and cellular proto-oncogenes and find a remarkable degree of co-mapping of tumor marker genes with oncogenes in the human karyotype. We propose that aberrant expression of marker genes in tumors may be related to their proximity in the human genome to oncogenes expresed during the development of malignancy, and we suggest ways to test this hypothesis of concerted abnormal gene expression in mammalian tumor cells.",

author = "Hozier, \{John C.\} and Mass, \{Marc J.\} and Siegfried, \{Jill M.\}",

note = "Funding Information: For critical reading of manuscript we thank Drs. Richard A. Rubin, Marcia Applegate, J. Herbert Taylor and David G. Kaufman. We thank Ms. Debbie LaFrance for expert editorial assistance and Natalie de Vassal for help with the statistical analysis. This report has been reviewed by the Health Effects Research Laboratory, U.S. Environmental Protection Agency and approved for publication. This work was supported by U.S. Environmental Protection Agency contract No. 68-02-4032 (J.M.S.) and U.S. Environmental Protection Agency grant No. R811773 (J.C.H.).",

year = "1987",

month = sep,

doi = "10.1016/0304-3835(87)90016-4",

language = "English (US)",

volume = "36",

pages = "235--245",

journal = "Cancer Letters",

issn = "0304-3835",

publisher = "Elsevier Ireland Ltd",

number = "3",

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TY - JOUR

T1 - Genes for tumor markers are clustered with cellular proto-onvogenes on human chromosomes

AU - Hozier, John C.

AU - Mass, Marc J.

AU - Siegfried, Jill M.

N1 - Funding Information: For critical reading of manuscript we thank Drs. Richard A. Rubin, Marcia Applegate, J. Herbert Taylor and David G. Kaufman. We thank Ms. Debbie LaFrance for expert editorial assistance and Natalie de Vassal for help with the statistical analysis. This report has been reviewed by the Health Effects Research Laboratory, U.S. Environmental Protection Agency and approved for publication. This work was supported by U.S. Environmental Protection Agency contract No. 68-02-4032 (J.M.S.) and U.S. Environmental Protection Agency grant No. R811773 (J.C.H.).

PY - 1987/9

Y1 - 1987/9

N2 - We have analyzed the relative mapping positions of genes for polypeptides expressed abnormally in tumors (tumor markers) and cellular proto-oncogenes and find a remarkable degree of co-mapping of tumor marker genes with oncogenes in the human karyotype. We propose that aberrant expression of marker genes in tumors may be related to their proximity in the human genome to oncogenes expresed during the development of malignancy, and we suggest ways to test this hypothesis of concerted abnormal gene expression in mammalian tumor cells.

AB - We have analyzed the relative mapping positions of genes for polypeptides expressed abnormally in tumors (tumor markers) and cellular proto-oncogenes and find a remarkable degree of co-mapping of tumor marker genes with oncogenes in the human karyotype. We propose that aberrant expression of marker genes in tumors may be related to their proximity in the human genome to oncogenes expresed during the development of malignancy, and we suggest ways to test this hypothesis of concerted abnormal gene expression in mammalian tumor cells.

UR - https://www.scopus.com/pages/publications/0023204903

UR - https://www.scopus.com/pages/publications/0023204903#tab=citedBy

U2 - 10.1016/0304-3835(87)90016-4

DO - 10.1016/0304-3835(87)90016-4

M3 - Review article

C2 - 3308073

AN - SCOPUS:0023204903

SN - 0304-3835

VL - 36

SP - 235

EP - 245

JO - Cancer Letters

JF - Cancer Letters

IS - 3

ER -

Genes for tumor markers are clustered with cellular proto-onvogenes on human chromosomes

Abstract

Bibliographical note

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