Abstract
We have analyzed the relative mapping positions of genes for polypeptides expressed abnormally in tumors (tumor markers) and cellular proto-oncogenes and find a remarkable degree of co-mapping of tumor marker genes with oncogenes in the human karyotype. We propose that aberrant expression of marker genes in tumors may be related to their proximity in the human genome to oncogenes expresed during the development of malignancy, and we suggest ways to test this hypothesis of concerted abnormal gene expression in mammalian tumor cells.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 235-245 |
| Number of pages | 11 |
| Journal | Cancer Letters |
| Volume | 36 |
| Issue number | 3 |
| DOIs | |
| State | Published - Sep 1987 |
Bibliographical note
Funding Information:For critical reading of manuscript we thank Drs. Richard A. Rubin, Marcia Applegate, J. Herbert Taylor and David G. Kaufman. We thank Ms. Debbie LaFrance for expert editorial assistance and Natalie de Vassal for help with the statistical analysis. This report has been reviewed by the Health Effects Research Laboratory, U.S. Environmental Protection Agency and approved for publication. This work was supported by U.S. Environmental Protection Agency contract No. 68-02-4032 (J.M.S.) and U.S. Environmental Protection Agency grant No. R811773 (J.C.H.).
