Genes for tumor markers are clustered with cellular proto-onvogenes on human chromosomes

John C. Hozier, Marc J. Mass, Jill M. Siegfried

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

We have analyzed the relative mapping positions of genes for polypeptides expressed abnormally in tumors (tumor markers) and cellular proto-oncogenes and find a remarkable degree of co-mapping of tumor marker genes with oncogenes in the human karyotype. We propose that aberrant expression of marker genes in tumors may be related to their proximity in the human genome to oncogenes expresed during the development of malignancy, and we suggest ways to test this hypothesis of concerted abnormal gene expression in mammalian tumor cells.

Original languageEnglish (US)
Pages (from-to)235-245
Number of pages11
JournalCancer Letters
Volume36
Issue number3
DOIs
StatePublished - Sep 1987

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