Generation of Th17 cells in response to intranasal infection requires TGF-β1 from dendritic cells and IL-6 from CD301b+ dendritic cells

Jonathan L. Linehan, Dileepan T, Sakeen W. Kashem, Daniel H Kaplan, Patrick Cleary, Marc Jenkins

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

Intranasal (i.n.) infections preferentially generate Th17 cells. We explored the basis for this anatomic preference by tracking polyclonal CD4+ T cells specific for an MHC class II-bound peptide from the mucosal pathogen Streptococcus pyogenes. S. pyogenes MHC class II-bound peptide-specific CD4+ T cells were first activated in the cervical lymph nodes following i.n. inoculation and then differentiated into Th17 cells. S. pyogenes-induced Th17 formation depended on TGF-β1 from dendritic cells and IL-6 from a CD301b+ dendritic cell subset located in the cervical lymph nodes but not the spleen. Thus, the tendency of i.n. infection to induce Th17 cells is related to cytokine production by specialized dendritic cells that drain this site.

Original languageEnglish (US)
Pages (from-to)12782-12787
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume112
Issue number41
DOIs
StatePublished - Oct 13 2015

Keywords

  • CD301b
  • Dendritic cells
  • Streptococcus pyogenes
  • Th17

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