Abstract
Regulatory T cells (Tregs) are generated to antigens (Ag) found in the retina. Some Tregs are the result of ectopic expression of the retinal Ags in the thymus, where developing T cells are committed to enter the regulatory lineage. However, the generation of retinal Ag-specific Tregs independent of the thymus was uncertain. Our studies show that Tregs can be generated from mature, peripheral T cells based on exposure to retinal Ags. These peripherally induced Tregs limited immune responses and experimental autoimmune disease induced by retinal Ags and thus constitute a crucial component of retinal immune privilege.
Original language | English (US) |
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Pages (from-to) | 344-349 |
Number of pages | 6 |
Journal | Current Immunology Reviews |
Volume | 7 |
Issue number | 3 |
DOIs | |
State | Published - Aug 2011 |
Keywords
- Immune privilege
- Regulatory t cells
- Retina