Generation of regulatory t cells to antigen expressed in the retina

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Abstract

Regulatory T cells (Tregs) are generated to antigens (Ag) found in the retina. Some Tregs are the result of ectopic expression of the retinal Ags in the thymus, where developing T cells are committed to enter the regulatory lineage. However, the generation of retinal Ag-specific Tregs independent of the thymus was uncertain. Our studies show that Tregs can be generated from mature, peripheral T cells based on exposure to retinal Ags. These peripherally induced Tregs limited immune responses and experimental autoimmune disease induced by retinal Ags and thus constitute a crucial component of retinal immune privilege.

Original languageEnglish (US)
Pages (from-to)344-349
Number of pages6
JournalCurrent Immunology Reviews
Volume7
Issue number3
DOIs
StatePublished - Aug 1 2011

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Keywords

  • Immune privilege
  • Regulatory t cells
  • Retina

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