Generation of Masked TiIIIntermediates from TiIVAmides via β-H Abstraction or Alkyne Deprotonation: An Example of Ti-Catalyzed Nitrene-Coupled Transfer Hydrogenation

Adam J. Pearce, Yukun Cheng, Rachel J. Dunscomb, Ian A. Tonks

Research output: Contribution to journalArticlepeer-review

Abstract

Simple Ti amide complexes are shown to act as sources for masked TiII intermediates via several pathways, as demonstrated through the investigation of a unique Ti-catalyzed nitrene-coupled transfer hydrogenation of 3-hexyne. This reaction proceeds through reduction of azobenzene by a masked TiII catalyst, wherein both amines and 3-hexyne can serve as the hydrogen source/reductant for Ti by forming putative titanaziridines via β-H abstraction or putative titanacyclopentynes via protonolysis, respectively.

Original languageEnglish (US)
Pages (from-to)3771-3774
Number of pages4
JournalOrganometallics
Volume39
Issue number21
DOIs
StatePublished - Nov 9 2020

Bibliographical note

Funding Information:
Financial support was provided by the National Institutes of Health (R35GM119457) and the Alfred P. Sloan Foundation (I.A.T. is a 2017 Sloan Fellow). Instrumentation for the University of Minnesota Chemistry NMR facility was supported from a grant through the National Institutes of Health (S10OD011952).

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