Generation and maintenance of immunological memory

Tania S. Gourley, E. John Wherry, David Masopust, Rafi Ahmed

Research output: Contribution to journalArticlepeer-review

183 Scopus citations


The key feature of the adaptive immune response is its specificity and the ability to generate and maintain memory. Preexisting antibodies in the circulation and at the mucosa provide the first line of defense against re-infection by extracellular as well as intracellular pathogens. Memory T cells are an important second line of defense against intracellular pathogens, and in particular against microbes that can cause chronic or latent infection. In this article we will review our current understanding of the generation and maintenance of B cell and T cell memory.

Original languageEnglish (US)
Pages (from-to)323-333
Number of pages11
JournalSeminars in Immunology
Issue number5
StatePublished - Oct 2004

Bibliographical note

Funding Information:
This work was supported by grant funding from the NIH (RA), the Leukemia and Lymphoma Society (TSG) and the Cancer Research Institute (EJW and DM).


  • Antibodies
  • CD8 T cells
  • Immune memory
  • Microbial infection
  • Plasma cell


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