Gene–Environment Interplay in Physical, Psychological, and Cognitive Domains in Mid to Late Adulthood: Is APOE a Variability Gene?

Chandra A. Reynolds, Margaret Gatz, Kaare Christensen, Lene Christiansen, Anna K. Dahl Aslan, Jaakko Kaprio, Tellervo Korhonen, William S. Kremen, Robert Krueger, Matt McGue, Jenae M. Neiderhiser, Nancy L. Pedersen

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Despite emerging interest in gene-environment interaction (GxE) effects, there is a dearth of studies evaluating its potential relevance apart from specific hypothesized environments and biometrical variance trends. Using a monozygotic within-pair approach, we evaluated evidence of G×E for body mass index (BMI), depressive symptoms, and cognition (verbal, spatial, attention, working memory, perceptual speed) in twin studies from four countries. We also evaluated whether APOE is a 'variability gene' across these measures and whether it partly represents the 'G' in G×E effects. In all three domains, G×E effects were pervasive across country and gender, with small-to-moderate effects. Age-cohort trends were generally stable for BMI and depressive symptoms; however, they were variable-with both increasing and decreasing age-cohort trends-for different cognitive measures. Results also suggested that APOE may represent a 'variability gene' for depressive symptoms and spatial reasoning, but not for BMI or other cognitive measures. Hence, additional genes are salient beyond APOE.
Original languageEnglish (US)
Pages (from-to)4-19
Number of pages16
JournalBehavior Genetics
Volume46
Issue number1
DOIs
StatePublished - Nov 4 2016

Keywords

  • APOE
  • BMI
  • Cognitive performance
  • Depression
  • Gene–environment interaction
  • Twins
  • Variability gene

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    Reynolds, C. A., Gatz, M., Christensen, K., Christiansen, L., Dahl Aslan, A. K., Kaprio, J., Korhonen, T., Kremen, W. S., Krueger, R., McGue, M., Neiderhiser, J. M., & Pedersen, N. L. (2016). Gene–Environment Interplay in Physical, Psychological, and Cognitive Domains in Mid to Late Adulthood: Is APOE a Variability Gene? Behavior Genetics, 46(1), 4-19. https://doi.org/10.1007/s10519-015-9761-3, https://doi.org/10.1007/s10519-015-9761-3