Gene transfer approaches to enhancing bone healing

Oliver Betz; Mark Vrahas; Axel Baltzer; Jay R. Lieberman; Paul D. Robbins; Christopher H. Evans

doi:10.1385/1-59259-863-3:157

Gene transfer approaches to enhancing bone healing

Oliver Betz, Mark Vrahas, Axel Baltzer, Jay R. Lieberman, Paul D. Robbins, Christopher H. Evans

Research output: Chapter in Book/Report/Conference proceeding › Chapter

9 Scopus citations

Abstract

Although bone is one of the few organs in the body that can heal spontaneously and restore function without scarring, it has been recognized since the time of Hippocrates that repair is not always satisfactory.Bone healing is inadequate when the loss of bone through, for example, tumor resection or traumatic injury, is extensive enough to produce a critical-sized defect.Healing may also be impaired in much smaller defects, and nonunion following fracture occurs in 5-10%of cases (1-3).

Original language	English (US)
Title of host publication	Bone Regeneration and Repair
Subtitle of host publication	Biology and Clinical Applications
Publisher	Humana Press
Pages	157-168
Number of pages	12
ISBN (Print)	0896038475, 9780896038479
DOIs	https://doi.org/10.1385/1-59259-863-3:157
State	Published - Dec 1 2005
Externally published	Yes

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T1 - Gene transfer approaches to enhancing bone healing

AU - Betz, Oliver

AU - Vrahas, Mark

AU - Baltzer, Axel

AU - Lieberman, Jay R.

AU - Robbins, Paul D.

AU - Evans, Christopher H.

PY - 2005/12/1

Y1 - 2005/12/1

N2 - Although bone is one of the few organs in the body that can heal spontaneously and restore function without scarring, it has been recognized since the time of Hippocrates that repair is not always satisfactory.Bone healing is inadequate when the loss of bone through, for example, tumor resection or traumatic injury, is extensive enough to produce a critical-sized defect.Healing may also be impaired in much smaller defects, and nonunion following fracture occurs in 5-10%of cases (1-3).

AB - Although bone is one of the few organs in the body that can heal spontaneously and restore function without scarring, it has been recognized since the time of Hippocrates that repair is not always satisfactory.Bone healing is inadequate when the loss of bone through, for example, tumor resection or traumatic injury, is extensive enough to produce a critical-sized defect.Healing may also be impaired in much smaller defects, and nonunion following fracture occurs in 5-10%of cases (1-3).

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SN - 9780896038479

SP - 157

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BT - Bone Regeneration and Repair

PB - Humana Press

ER -

Gene transfer approaches to enhancing bone healing

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