Gene therapy for established murine collagen-induced arthritis bylocal and systemic adenovirus-madiated delivery of interleukin-4

S. H. Kim, C. H. Evans, S. Kim, T. Oligino, S. C. Ghivizzani, P. D. Robbins

Research output: Contribution to journalArticlepeer-review

86 Scopus citations

Abstract

To determine whether IL-4 is therapeutic in treating established experimental arthritis, a recombinant adenovirus carrying the gene that encodes murine IL-4 (Ad-mlL-4) was used for periarticular injection into the ankle joints into mice with established collagen-induced arthritis (CIA). Periarticular injection of Ad-mlL-4 resulted in a reduction in the severity of arthritis and joint swelling compared with saline and adenoviral control groups. Local expression of IL-4 also reduced macroscopic signs of joint inflammation and bone erosion. Moreover, injection of Ad-mlL-4 into the hind ankle joints resulted in a decrease in disease severity in the untreated front paws. Systemic delivery of murine IL-4 by intravenous injection of Ad-mlL-4 resulted in a significant reduction in the severity of early-stage arthritis.

Original languageEnglish (US)
Pages (from-to)293-302
Number of pages10
JournalArthritis Research
Volume2
Issue number4
DOIs
StatePublished - 2000

Keywords

  • Adenoviral vectors
  • Collagen-induced arthritis
  • Gene therapy
  • IL-10
  • IL-4
  • Rheumatoid arthritis

Fingerprint Dive into the research topics of 'Gene therapy for established murine collagen-induced arthritis bylocal and systemic adenovirus-madiated delivery of interleukin-4'. Together they form a unique fingerprint.

Cite this