Gene-drug interaction at the glucocorticoid receptor increases risk of squamous cell skin cancer

Anita S. Patel, Margaret R. Karagas, Ann E. Perry, Steven K. Spencer, Heather H. Nelson

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Non-melanoma skin cancers (NMSCs) are the most common malignancy among US Caucasians. Using a population-based study of NMSC we found that oral steroid use is associated with nearly 6-fold elevated risk of squamous cell carcinoma among individuals with a common genetic variant in the steroid receptor (NR3C1) gene. Given the large numbers of individuals on immunosuppressive drug therapy for inflammatory disease, these findings have important implications for NMSC screening and prevention.

Original languageEnglish (US)
Pages (from-to)1868-1870
Number of pages3
JournalJournal of Investigative Dermatology
Volume127
Issue number8
DOIs
StatePublished - Aug 2007

Bibliographical note

Funding Information:
We are indebted to the NH Society of Dermatology and participating dermatologists for their collaboration. This study was supported by the National Cancer Institute Grants R01 CA 8354 and R01 CA 57494.

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