Gene-drug interaction at the glucocorticoid receptor increases risk of squamous cell skin cancer

Anita S. Patel; Margaret R. Karagas; Ann E. Perry; Steven K. Spencer; Heather H. Nelson

doi:10.1038/sj.jid.5700798

Gene-drug interaction at the glucocorticoid receptor increases risk of squamous cell skin cancer

Anita S. Patel, Margaret R. Karagas, Ann E. Perry, Steven K. Spencer, Heather H. Nelson

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16 Scopus citations

Abstract

Non-melanoma skin cancers (NMSCs) are the most common malignancy among US Caucasians. Using a population-based study of NMSC we found that oral steroid use is associated with nearly 6-fold elevated risk of squamous cell carcinoma among individuals with a common genetic variant in the steroid receptor (NR3C1) gene. Given the large numbers of individuals on immunosuppressive drug therapy for inflammatory disease, these findings have important implications for NMSC screening and prevention.

Original language	English (US)
Pages (from-to)	1868-1870
Number of pages	3
Journal	Journal of Investigative Dermatology
Volume	127
Issue number	8
DOIs	https://doi.org/10.1038/sj.jid.5700798
State	Published - Aug 2007

Bibliographical note

Funding Information:
We are indebted to the NH Society of Dermatology and participating dermatologists for their collaboration. This study was supported by the National Cancer Institute Grants R01 CA 8354 and R01 CA 57494.

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title = "Gene-drug interaction at the glucocorticoid receptor increases risk of squamous cell skin cancer",

abstract = "Non-melanoma skin cancers (NMSCs) are the most common malignancy among US Caucasians. Using a population-based study of NMSC we found that oral steroid use is associated with nearly 6-fold elevated risk of squamous cell carcinoma among individuals with a common genetic variant in the steroid receptor (NR3C1) gene. Given the large numbers of individuals on immunosuppressive drug therapy for inflammatory disease, these findings have important implications for NMSC screening and prevention.",

author = "Patel, {Anita S.} and Karagas, {Margaret R.} and Perry, {Ann E.} and Spencer, {Steven K.} and Nelson, {Heather H.}",

note = "Funding Information: We are indebted to the NH Society of Dermatology and participating dermatologists for their collaboration. This study was supported by the National Cancer Institute Grants R01 CA 8354 and R01 CA 57494.",

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AU - Perry, Ann E.

AU - Spencer, Steven K.

AU - Nelson, Heather H.

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Gene-drug interaction at the glucocorticoid receptor increases risk of squamous cell skin cancer

Abstract

Bibliographical note

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