Gene-based dose optimization in children

Laura B. Ramsey, Jacob T. Brown, Susan I. Vear, Jeffrey R. Bishop, Sara L. Van Driest

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

Pharmacogenetics is a key component of precision medicine. Genetic variation in drug metabolism enzymes can lead to variable exposure to drugs and metabolites, potentially leading to inefficacy and drug toxicity. Although the evidence for pharmacogenetic associations in children is not as extensive as for adults, there are several drugs across diverse therapeutic areas with robust pediatric data indicating important, and relatively common, drug-gene interactions. Guidelines to assist gene-based dose optimization are available for codeine, thiopurine drugs, selective serotonin reuptake inhibitors, atomoxetine, tacrolimus, and voriconazole. For each of these drugs, there is an opportunity to clinically implement precision medicine approaches with children for whom genetic test results are known or are obtained at the time of prescribing. For many more drugs that are commonly used in pediatric patients, additional investigation is needed to determine the genetic factors influencing appropriate dose.

Original languageEnglish (US)
Pages (from-to)311-331
Number of pages21
JournalAnnual review of pharmacology and toxicology
Volume60
DOIs
StatePublished - Jan 6 2020

Keywords

  • immunology
  • infectious disease
  • oncology
  • pediatrics
  • pharmacogenomics
  • psychiatry

PubMed: MeSH publication types

  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural

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