Gaussian curvature and the equilibrium among bilayer cylinders, spheres, and discs

H. T. Jung, S. Y. Lee, E. W. Kaler, B. Coldren, J. A. Zasadzinski

Research output: Contribution to journalArticlepeer-review

122 Scopus citations

Abstract

In mixtures of cetyltrimethylammonium bromide (CTAB) and sodium perfluorooctanoate (FC7) in aqueous solution, novel bilayer cylinders with hemispherical end caps and open, flat discs coexist with spherical unilamellar vesicles, apparently at equilibrium. Such equilibrium among bilayer cylinders, spheres, and discs is only possible for systems with a spontaneous curvature, Ro, and a positive Gaussian curvature modulus, Κ. We have measured the size distributions of the spherical vesicles, cylinders, and discs by using cryo-electron microscopy; a simple analysis of this length distribution allows us to independently determine that the mean curvature modulus, Κ ≈ 5 ± 1 kBT and Κ 2 ± 1 kBT. This is one of the few situations in which Ro, Κ, and Κ can be determined from the same experiment. From a similar analysis of the disk size distribution, we find that the edges of the discs are likely stabilized by excess CTAB. The fraction of discs, spherical vesicles, and cylinders depends on the CTAB/FC7 mole ratio: increasing CTAB favors discs, while decreasing CTAB favors cylinders. This control over aggregate shape with surfactant concentration may be useful for the design of templates for polymerization, mesoporous silicates, etc.

Original languageEnglish (US)
Pages (from-to)15318-15322
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume99
Issue number24
DOIs
StatePublished - Nov 26 2002

Keywords

  • Cryogenic transmission electron microscopy
  • Surfactants
  • Vesicles

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