Gastrointestinal stromal tumor surgery and adjuvant therapy

Valerie P. Grignol, Paula M. Termuhlen

Research output: Contribution to journalReview articlepeer-review

23 Scopus citations

Abstract

Gastrointestinal stromal tumors (GIST) are a unique class of mesenchymal tumors identified within the past decade. Intense molecular and genetic study has been used to characterize these tumors and develop treatment strategies. Although the mainstay of treatment remains surgical resection, therapy targeted at inhibiting tyrosine kinases has had dramatic results. Because of the rapid accumulation of information about the diagnosis and treatment of these tumors, the National Comprehensive Cancer Network convened a GIST task force to provide updated recommendations in 2010. As understanding of these tumors advances, rapid changes in recommendations will continue and should warrant regular updates in tumor management.

Original languageEnglish (US)
Pages (from-to)1079-1087
Number of pages9
JournalSurgical Clinics of North America
Volume91
Issue number5
DOIs
StatePublished - Oct 1 2011

Keywords

  • GIST
  • Gastrointestinal stromal tumor
  • Imatinib mesylate
  • KIT
  • PDGFRA

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