Gastrointestinal prokinetic therapy: Dopaminergic antagonist drugs

Jean A. Hall, Robert J. Washabau

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Motility disorders of the esophagus, stomach, small intestine, and colon are common in dogs and cats. These disorders have usually been treated primarily by dietary management and surgical intervention; however, gastrointestinal prokinetic therapy is assuming increasing clinical importance. In parts I through IV of this five-part Continuing Education Series, gastrointestinal prokinetic agents are grouped into four categories. For each category of agents, the mechanisms of action, site of activity, and indications for use will be discussed. Part I contains information about the dopaminergic antagonist drugs, which inhibit peripheral and/or central dopamine receptors. Metoclopramide and domperidone, for example, reverse the gastric relaxation induced by dopamine infusion in dogs. The agents abolish the vomiting that is associated with apomorphine administration. Part II of the series will deal with motilin-like drugs, Part III will consider serotonergic drugs, and part IV will discuss the acetylcholinesterase inhibitors or parasympathetic potentiating drugs. The final part will deal with the diagnosis and management of esophageal, gastric, and colonic motility disorders; clinical preferences for gastrointestinal prokinetic agents will be highlighted.

Original languageEnglish (US)
Pages (from-to)214-220
Number of pages7
JournalCompendium on Continuing Education for the Practicing Veterinarian
Volume19
Issue number2
StatePublished - Feb 1 1997

Fingerprint

Dopamine Agents
Dopamine Antagonists
gastrointestinal agents
Gastrointestinal Agents
antagonists
Stomach
drug
drugs
therapeutics
stomach
Dogs
Motilin
Domperidone
Serotonin Agents
Metoclopramide
Apomorphine
motilin
Cholinesterase Inhibitors
Continuing Education
apomorphine

Cite this

Gastrointestinal prokinetic therapy : Dopaminergic antagonist drugs. / Hall, Jean A.; Washabau, Robert J.

In: Compendium on Continuing Education for the Practicing Veterinarian, Vol. 19, No. 2, 01.02.1997, p. 214-220.

Research output: Contribution to journalArticle

@article{26fdd1e6f3844dbaa2bb341dc016fcfb,
title = "Gastrointestinal prokinetic therapy: Dopaminergic antagonist drugs",
abstract = "Motility disorders of the esophagus, stomach, small intestine, and colon are common in dogs and cats. These disorders have usually been treated primarily by dietary management and surgical intervention; however, gastrointestinal prokinetic therapy is assuming increasing clinical importance. In parts I through IV of this five-part Continuing Education Series, gastrointestinal prokinetic agents are grouped into four categories. For each category of agents, the mechanisms of action, site of activity, and indications for use will be discussed. Part I contains information about the dopaminergic antagonist drugs, which inhibit peripheral and/or central dopamine receptors. Metoclopramide and domperidone, for example, reverse the gastric relaxation induced by dopamine infusion in dogs. The agents abolish the vomiting that is associated with apomorphine administration. Part II of the series will deal with motilin-like drugs, Part III will consider serotonergic drugs, and part IV will discuss the acetylcholinesterase inhibitors or parasympathetic potentiating drugs. The final part will deal with the diagnosis and management of esophageal, gastric, and colonic motility disorders; clinical preferences for gastrointestinal prokinetic agents will be highlighted.",
author = "Hall, {Jean A.} and Washabau, {Robert J.}",
year = "1997",
month = "2",
day = "1",
language = "English (US)",
volume = "19",
pages = "214--220",
journal = "Compendium on Continuing Education for the Practicing Veterinarian",
issn = "0193-1903",
publisher = "Veterinary Learning Systems",
number = "2",

}

TY - JOUR

T1 - Gastrointestinal prokinetic therapy

T2 - Dopaminergic antagonist drugs

AU - Hall, Jean A.

AU - Washabau, Robert J.

PY - 1997/2/1

Y1 - 1997/2/1

N2 - Motility disorders of the esophagus, stomach, small intestine, and colon are common in dogs and cats. These disorders have usually been treated primarily by dietary management and surgical intervention; however, gastrointestinal prokinetic therapy is assuming increasing clinical importance. In parts I through IV of this five-part Continuing Education Series, gastrointestinal prokinetic agents are grouped into four categories. For each category of agents, the mechanisms of action, site of activity, and indications for use will be discussed. Part I contains information about the dopaminergic antagonist drugs, which inhibit peripheral and/or central dopamine receptors. Metoclopramide and domperidone, for example, reverse the gastric relaxation induced by dopamine infusion in dogs. The agents abolish the vomiting that is associated with apomorphine administration. Part II of the series will deal with motilin-like drugs, Part III will consider serotonergic drugs, and part IV will discuss the acetylcholinesterase inhibitors or parasympathetic potentiating drugs. The final part will deal with the diagnosis and management of esophageal, gastric, and colonic motility disorders; clinical preferences for gastrointestinal prokinetic agents will be highlighted.

AB - Motility disorders of the esophagus, stomach, small intestine, and colon are common in dogs and cats. These disorders have usually been treated primarily by dietary management and surgical intervention; however, gastrointestinal prokinetic therapy is assuming increasing clinical importance. In parts I through IV of this five-part Continuing Education Series, gastrointestinal prokinetic agents are grouped into four categories. For each category of agents, the mechanisms of action, site of activity, and indications for use will be discussed. Part I contains information about the dopaminergic antagonist drugs, which inhibit peripheral and/or central dopamine receptors. Metoclopramide and domperidone, for example, reverse the gastric relaxation induced by dopamine infusion in dogs. The agents abolish the vomiting that is associated with apomorphine administration. Part II of the series will deal with motilin-like drugs, Part III will consider serotonergic drugs, and part IV will discuss the acetylcholinesterase inhibitors or parasympathetic potentiating drugs. The final part will deal with the diagnosis and management of esophageal, gastric, and colonic motility disorders; clinical preferences for gastrointestinal prokinetic agents will be highlighted.

UR - http://www.scopus.com/inward/record.url?scp=3042734213&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=3042734213&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:3042734213

VL - 19

SP - 214

EP - 220

JO - Compendium on Continuing Education for the Practicing Veterinarian

JF - Compendium on Continuing Education for the Practicing Veterinarian

SN - 0193-1903

IS - 2

ER -