Gastrointestinal perforations in renal transplant recipients immunosuppressed with cyclosporin

Paolo Rigotti, Charles T. Van Buren, William D. Payne, Charles Peters, Barry D. Kahan

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14 Scopus citations


Gastrointestinal perforations frequently represent a lethal complication of immunosuppression. Of 325 renal transplant recipients treated with cyclosporin (CsA), 4 patients (1.2%) developed gastrointestinal perforation: 1 from gastric ulcer and 3 from colonic diverticula. All patients underwent operative treatment and all survived without complications. Three patients maintained a well-functioning allograft. In comparison to azathioprine, CsA does not seem to greatly affect the immune response to bacterial infections, thus representing a considerable advantage in the management of serious gastrointestinal complications.

Original languageEnglish (US)
Pages (from-to)137-141
Number of pages5
JournalWorld Journal of Surgery
Issue number1
StatePublished - Feb 1986


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