Gastrointestinal cryptococcoma - Immune reconstitution inflammatory syndrome or cryptococcal relapse in a patient with AIDS?

Abdu K. Musubire, David B. Meya, Robert Lukande, Andrew Kambugu, Paul R. Bohjanen, David R. Boulware

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


The introduction of antiretroviral therapy (ART) may lead to unusual paradoxical and unmasking presentations of opportunistic infections. Intra-abdominal cryptococcosis is a rare manifestation of Cryptococcus. We present the case of an HIV-infected patient on ART, with a history of cryptococcal meningitis who presented with subacute, worsening abdominal pain during immune recovery. This evolved into chronic abdominal pain, with thickened bowel, and abdominal lymphadenopathy, while receiving empiric tuberculosis treatment. At 6-months, he developed intestinal perforation due to a histologically confirmed cryptococcoma.

Original languageEnglish (US)
Pages (from-to)40-43
Number of pages4
JournalMedical Mycology Case Reports
StatePublished - Jun 1 2015

Bibliographical note

Funding Information:
We thank Ms. Jane Ndyetukira and Ms. Irene Namugga for patient care. This work was supported in part by the NIH National Institute of Allergy and Infectious Diseases, United States ( R25TW009345 ; T32AI055433 ; U01AI089244 ; K23AI073192 ; K24AI096925 ), Minnesota Medical Foundation through the Robert and Mabel Bohjanen Immune Reconstitution Research Fund, Tibotec REACH Initiative, University of Minnesota Translational Research Grant, University of Minnesota Office of International Programs.

Publisher Copyright:
© 2015 Published by Elsevier B.V. on behalf of International Society for Human and Animal Mycology.


  • AIDS
  • Antiretroviral therapy
  • Cryptococcal meningitis
  • Cryptococcoma
  • HIV
  • Immune reconstitution inflammatory syndrome


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