Gastrointestinal cancer and the cystic fibrosis gene

M. William Audeh, Joseph P. Neglia, Stacey C. Fitzsimmons, Albert B. Lowenfels

Research output: Contribution to journalLetterpeer-review

3 Scopus citations


To the Editor: Neglia et al. (Feb. 23 issue)1 report an increased incidence of gastrointestinal cancer in patients with cystic fibrosis and suggest a relation between the action of the defective gene and the development of cancer in the gastrointestinal tract. If this relation is confirmed, the gene for cystic fibrosis may be added to the growing list of genes conferring an increased risk of cancer and may be the first example of a more widespread biologic phenomenon: the role of evolutionary biology in cancer genetics. Since 1 in 25 to 50 white persons carries the gene for cystic fibrosis,. . .

Original languageEnglish (US)
Pages (from-to)129-130
Number of pages2
JournalNew England Journal of Medicine
Issue number2
StatePublished - Jul 13 1995


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