Gastroesophageal Reflux Disease Outcomes After Vertical Sleeve Gastrectomy and Gastric Bypass

Daniel Leslie, Eric Wise, Adam Sheka, Hisham Abdelwahab, Ryan Irey, Ashley Benner, Sayeed Ikramuddin

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Objective: The objective of this study is to assess whether vertical sleeve gastrectomy (VSG) increases the incidence of gastroesophageal reflux disease (GERD), esophagitis and Barrett esophagus (BE) relative to patients undergoing Roux-en-Y gastric bypass (RYGB) in patients with and without preoperative GERD. Summary of Background Data: Concerns for potentiation of GERD, supported by multiple high-quality retrospective studies, have hindered greater adoption of the VSG. Methods: From the OptumLabs Data Warehouse, VSG and RYGB patients with ≥2 years enrollment were identified and matched by follow-up time. GERD [reflux esophagitis, prescription for acid reducing medication (Rx) and/or diagnosis of BE], upper endoscopy (UE), and re-admissions were evaluated beyond 90 days. Results: Atotal of 8362 patients undergoing VSGwerematched 1:1 to patients undergoing RYGB, on the basis of post-operative follow-up interval. Age, sex, and follow-up time were similar between the 2 groups (P > 0.05). Among all patients, postoperative GERD was more frequently observed in VSG patients relative to RYGB patients (60.2% vs 55.6%, respectively; P < 0.001), whereas BE was more prevalent in RYGB patients (0.7% vs 1.1%; P = 0.007). Postoperatively, de novo esophageal reflux symptomatologywas more common in VSGpatients (39.3% vs 35.3%; P<0.001), although there was no difference in development of the histologic diagnoses reflux esophagitis and BE. Furthermore, postoperative re-admission was higher in the RYGB cohort (38.9% vs 28.9%; P < 0.001). Conclusions: Compared to RYGB, VSG may not have inferior long-term GERD outcomes, while also leading to fewer re-hospitalizations. These data challenge the prevailing opinion that patients with GERD should undergo RYGB instead of VSG.

Original languageEnglish (US)
Pages (from-to)646-653
Number of pages8
JournalAnnals of surgery
Issue number4
StatePublished - Oct 1 2021

Bibliographical note

Publisher Copyright:
Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.


  • Adult
  • Barrett Esophagus/epidemiology
  • Esophagitis/epidemiology
  • Female
  • Gastrectomy/adverse effects
  • Gastric Bypass/adverse effects
  • Gastroesophageal Reflux/epidemiology
  • Humans
  • Incidence
  • Male
  • Middle Aged
  • Obesity, Morbid/complications
  • Postoperative Complications/epidemiology
  • Retrospective Studies
  • Treatment Outcome

PubMed: MeSH publication types

  • Journal Article


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