Solute retention in capillary GC columns can be correlated with a linear salvation energy relationship (LSER) equation using chromatographically determined solute parameters (log L16, π2*,C, α 2c and β2c. The LSER coefficients obtained from correlation studies serve to quantitatively characterize the stationary phase. The effect of column temperature on retention was characterized by the temperature dependence of the LSER coefficients. Enthalpy and entropy of the retention process were also fitted quite well to the LSER equation. The main contributions to retention are from the solute-solvent interactions that give large favorable enthalpies and small unfavorable entropies. The LSER coefficients for the free energy and enthalpy regressions are linearly correlated.
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This work was supportedi n part by grants to the University of Minnesota from the National ScienceF oundation and the Petroleum Research Foundation.