Ganciclovir-resistant cytomegalovirus encephalitis in a bone marrow transplant recipient

J. E. Julin, J. H. Van Burik, W. Krivit, C. Webb, C. J. Holman, H. B. Clark, Henry H. Balfour

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39 Scopus citations


A 20-year-old patient, who received a bone marrow transplant in order to treat metachromatic leukodystrophy (MLD), succumbed to cytomegalovirus (CMV) encephalitis. After CMV viremia developed, the patient received ganciclovir, but he was switched to foscarnet when ganciclovir resistance was suspected. Foscarnet was discontinued because of concern about its potential central nervous system toxicity. Autopsy samples of brain and cerebrospinal fluid contained CMV DNA with a UL97 mutation (M460V) known to confer ganciclovir resistance. No foscarnet resistance mutations were found.

Original languageEnglish (US)
Pages (from-to)201-206
Number of pages6
JournalTransplant Infectious Disease
Issue number4
StatePublished - Dec 2002


  • Cytomegalovirus
  • Encephalitis
  • Ganciclovir resistance
  • Metachromatic leukodystrophy
  • Transplantation
  • UL97 mutation


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