Gamma interferon induces detectable serological and functional expression of DR and DP but not DQ antigens on cultured amniotic fluid cells

D. H. Maurer, C. Callaway, S. Sorkin, M. S. Pollack

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Cultured amniotic fluid cells, which are used for HLA typing studies for the prenatal diagnosis of HLA linked diseases and for prenatal determination of paternity, usually contain mixtures of fibroblastic and epithelioid cells. Cells of both types lack constitutive expression of HLA class II antigens, but these can be induced by pretreatment with gamma interferon. Both serological and functional studies indicate that detectable levels of DR and DP but not DQ antigens can be thereby induced. DR and DP cannot, however, be induced on chorionic villus cells.

Original languageEnglish (US)
Pages (from-to)174-182
Number of pages9
JournalTissue Antigens
Volume31
Issue number4
DOIs
StatePublished - Apr 1988

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