Galectins as therapeutic targets for hematological malignancies: A hopeful sweetness

Camilo Pena; Leonardo Mirandola; Jose A. Figueroa; Nattamol Hosiriluck; Natallia Suvorava; Kayley Trotter; Adair Reidy; Rahman Rakhshanda; Drew Payne; Marjorie Jenkins; Fabio Grizzi; Lauren Littlefield; Maurizio Chiriva-Internati; Everardo Cobos

doi:10.3978/j.issn.2305-5839.2014.09.14

Galectins as therapeutic targets for hematological malignancies: A hopeful sweetness

Camilo Pena
, Leonardo Mirandola
, Jose A. Figueroa
, Nattamol Hosiriluck
, Natallia Suvorava
, Kayley Trotter
, Adair Reidy
, Rahman Rakhshanda
, Drew Payne
, Marjorie Jenkins
, Fabio Grizzi
, Lauren Littlefield
, Maurizio Chiriva-Internati
, Everardo Cobos

Medicine - Hematology, Oncology, Transplant

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Galectins are family of galactose-binding proteins known to play critical roles in inflammation and neoplastic progression. Galectins facilitate the growth and survival of neoplastic cells by regulating their cross-talk with the extracellular microenvironment and hampering anti-neoplastic immunity. Here, we review the role of galectins in the biology of hematological malignancies and their promise as potential therapeutic agents in these diseases.

Original language	English (US)
Article number	87
Journal	Annals of Translational Medicine
Volume	2
Issue number	9
DOIs	https://doi.org/10.3978/j.issn.2305-5839.2014.09.14
State	Published - Sep 2014

Bibliographical note

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© Annals of Translational Medicine. All rights reserved.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Galectin-3 (Gal-3)
Galectins
Leukemia
Lymphomas
Multiple myeloma (MM)

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Pena, C., Mirandola, L., Figueroa, J. A., Hosiriluck, N., Suvorava, N., Trotter, K., Reidy, A., Rakhshanda, R., Payne, D., Jenkins, M., Grizzi, F., Littlefield, L., Chiriva-Internati, M., & Cobos, E. (2014). Galectins as therapeutic targets for hematological malignancies: A hopeful sweetness. Annals of Translational Medicine, 2(9), Article 87. https://doi.org/10.3978/j.issn.2305-5839.2014.09.14

Pena, C, Mirandola, L, Figueroa, JA, Hosiriluck, N, Suvorava, N, Trotter, K, Reidy, A, Rakhshanda, R, Payne, D, Jenkins, M, Grizzi, F, Littlefield, L, Chiriva-Internati, M & Cobos, E 2014, 'Galectins as therapeutic targets for hematological malignancies: A hopeful sweetness', Annals of Translational Medicine, vol. 2, no. 9, 87. https://doi.org/10.3978/j.issn.2305-5839.2014.09.14

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abstract = "Galectins are family of galactose-binding proteins known to play critical roles in inflammation and neoplastic progression. Galectins facilitate the growth and survival of neoplastic cells by regulating their cross-talk with the extracellular microenvironment and hampering anti-neoplastic immunity. Here, we review the role of galectins in the biology of hematological malignancies and their promise as potential therapeutic agents in these diseases.",

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AU - Suvorava, Natallia

AU - Trotter, Kayley

AU - Reidy, Adair

AU - Rakhshanda, Rahman

AU - Payne, Drew

AU - Jenkins, Marjorie

AU - Grizzi, Fabio

AU - Littlefield, Lauren

AU - Chiriva-Internati, Maurizio

AU - Cobos, Everardo

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AB - Galectins are family of galactose-binding proteins known to play critical roles in inflammation and neoplastic progression. Galectins facilitate the growth and survival of neoplastic cells by regulating their cross-talk with the extracellular microenvironment and hampering anti-neoplastic immunity. Here, we review the role of galectins in the biology of hematological malignancies and their promise as potential therapeutic agents in these diseases.

KW - Galectin-3 (Gal-3)

KW - Galectins

KW - Leukemia

KW - Lymphomas

KW - Multiple myeloma (MM)

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Galectins as therapeutic targets for hematological malignancies: A hopeful sweetness

Abstract

Bibliographical note

UN SDGs

Keywords

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