Galectins as molecular targets for therapeutic intervention

Ruud P.M. Dings, Michelle C. Miller, Robert J. Griffin, Kevin H. Mayo

Research output: Contribution to journalReview articlepeer-review

60 Scopus citations

Abstract

Galectins are a family of small, highly conserved, molecular effectors that mediate various biological processes, including chemotaxis and angiogenesis, and that function by interacting with various cell surface glycoconjugates, usually targeting β-galactoside epitopes. Because of their significant involvement in various biological functions and pathologies, galectins have become a focus of therapeutic discovery for clinical intervention against cancer, among other pathological disorders. In this review, we focus on understanding galectin structure-function relationships, their mechanisms of action on the molecular level, and targeting them for therapeutic intervention against cancer.

Original languageEnglish (US)
Article number905
JournalInternational journal of molecular sciences
Volume19
Issue number3
DOIs
StatePublished - Mar 19 2018

Bibliographical note

Publisher Copyright:
© 2018 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

  • Apoptosis
  • Cancer
  • Carbohydrates
  • Cell adhesion
  • Galectins
  • Galectintargeted therapeutics
  • Protein structure

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