GALAD score for hepatocellular carcinoma detection in comparison with liver ultrasound and proposal of Galadus score

Ju Dong Yang, Benyam D. Addissie, Kristin C. Mara, William S. Harmsen, Jianliang Dai, Ning Zhang, Nicha Wongjarupong, Hawa M. Ali, Hamdi A. Ali, Fatima A. Hassan, Sravanthi Lavu, Jessica L. Cvinar, Nasra H. Giama, Catherine D. Moser, Katsuyuki Miyabe, Loretta K. Allotey, Alicia Algeciras-Schimnich, J. Paul Theobald, Melissa M. Ward, Mindie H. NguyenAlex S. Befeler, K. Rajender Reddy, Myron Schwartz, Denise M. Harnois, Hiroyuki Yamada, Sudhir Srivastava, Jo Ann Rinaudo, Gregory J. Gores, Ziding Feng, Jorge A. Marrero, Lewis R. Roberts

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Background: The GALAD score is a serum biomarker–sensitivity of 91% and a specificity of 85% for HCC detection. based model that predicts the probability of having The AUC of the GALAD score for early-stage HCC detection hepatocellular carcinoma (HCC) in patients with chronic remained high at 0.92 (95% CI, 0.88–0.96; cutoff 1.18, liver disease. We aimed to assess the performance of the sensitivity 92%, specificity 79%). The AUC of the GALAD GALAD score in comparison with liver ultrasound for score for HCC detection was 0.88 (95% CI, 0.85–0.91) in the detection of HCC. EDRN cohort. The combination of GALAD and ultrasound Methods: A single-center cohort of 111 HCC patients and (GALADUS score) further improved the performance of the 180 controls with cirrhosis or chronic hepatitis B and a GALAD score in the single-center cohort, achieving an AUC multicenter cohort of 233 early HCC and 412 cirrhosis of 0.98 (95% CI, 0.96–0.99; cutoff 0.18, sensitivity 95%, patients from the Early Detection Research Network (EDRN) specificity 91%). phase II HCC Study were analyzed. Conclusions: The performance of the GALAD score was Results: The area under the ROC curve (AUC) of the GALAD superior to ultrasound for HCC detection. The GALADUS score for HCC detection was 0.95 [95% confidence interval score further enhanced the performance of the GALAD score. (CI), 0.93–97], which was higher than the AUC of ultrasound Impact: The GALAD score was validated in the United (0.82, P <0.01). At a cutoff of 0.76, the GALAD score had a States.

Original languageEnglish (US)
Pages (from-to)531-538
Number of pages8
JournalCancer Epidemiology Biomarkers and Prevention
Volume28
Issue number3
DOIs
StatePublished - Mar 2019
Externally publishedYes

PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural

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    Yang, J. D., Addissie, B. D., Mara, K. C., Harmsen, W. S., Dai, J., Zhang, N., Wongjarupong, N., Ali, H. M., Ali, H. A., Hassan, F. A., Lavu, S., Cvinar, J. L., Giama, N. H., Moser, C. D., Miyabe, K., Allotey, L. K., Algeciras-Schimnich, A., Theobald, J. P., Ward, M. M., ... Roberts, L. R. (2019). GALAD score for hepatocellular carcinoma detection in comparison with liver ultrasound and proposal of Galadus score. Cancer Epidemiology Biomarkers and Prevention, 28(3), 531-538. https://doi.org/10.1158/1055-9965.EPI-18-0281