GALACTOSE CONSUMPTION AND METABOLISM IN RELATION TO THE RISK OF OVARIAN CANCER

Daniel W. Cramer; Walter C. Willett; Debra A. Bell; Won G. Ng; Bernard L. Harlow; William R. Welch; Robert E. Scully; Robert C. Knapp

doi:10.1016/S0140-6736(89)90313-9

GALACTOSE CONSUMPTION AND METABOLISM IN RELATION TO THE RISK OF OVARIAN CANCER

Daniel W. Cramer, Walter C. Willett, Debra A. Bell, Won G. Ng, Bernard L. Harlow, William R. Welch, Robert E. Scully, Robert C. Knapp

Epidemiology & Community Health

Research output: Contribution to journal › Article › peer-review

151 Scopus citations

Abstract

In a case-control study, consumption of dairy foods by 235 white women with epithelial ovarian cancer and by 239 control women, and activity of red blood cell galactose-1-phosphate uridyl transferase (transferase) in a subset of 145 cases and 127 controls were determined. Yogurt was consumed at least monthly by 49% of cases and 36% of controls. The mean transferase activity of cases was significantly lower than that of controls. When a ratio of lactose consumption to transferase (L/T) was calculated, cases had a mean L/T of 1·17 compared with 0·98 for controls; there was a highly significant trend for increasing ovarian cancer risk with increasing L/T ratio. Lactose consumption may be a dietary risk factor and transferase a genetic risk factor for ovarian cancer.

Original language	English (US)
Pages (from-to)	66-71
Number of pages	6
Journal	The Lancet
Volume	334
Issue number	8654
DOIs	https://doi.org/10.1016/S0140-6736(89)90313-9
State	Published - Jul 8 1989

Bibliographical note

Funding Information:
Ms Leslie Fortier, Ms Dawn Harvey, Ms Judy Geller, and Ms Emily Lublin is gratefully acknowledged. This study was supported by grant R01 CA 42008 from the National Cancer Institute.

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title = "GALACTOSE CONSUMPTION AND METABOLISM IN RELATION TO THE RISK OF OVARIAN CANCER",

abstract = "In a case-control study, consumption of dairy foods by 235 white women with epithelial ovarian cancer and by 239 control women, and activity of red blood cell galactose-1-phosphate uridyl transferase (transferase) in a subset of 145 cases and 127 controls were determined. Yogurt was consumed at least monthly by 49% of cases and 36% of controls. The mean transferase activity of cases was significantly lower than that of controls. When a ratio of lactose consumption to transferase (L/T) was calculated, cases had a mean L/T of 1·17 compared with 0·98 for controls; there was a highly significant trend for increasing ovarian cancer risk with increasing L/T ratio. Lactose consumption may be a dietary risk factor and transferase a genetic risk factor for ovarian cancer.",

author = "Cramer, {Daniel W.} and Willett, {Walter C.} and Bell, {Debra A.} and Ng, {Won G.} and Harlow, {Bernard L.} and Welch, {William R.} and Scully, {Robert E.} and Knapp, {Robert C.}",

note = "Funding Information: Ms Leslie Fortier, Ms Dawn Harvey, Ms Judy Geller, and Ms Emily Lublin is gratefully acknowledged. This study was supported by grant R01 CA 42008 from the National Cancer Institute.",

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doi = "10.1016/S0140-6736(89)90313-9",

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AU - Cramer, Daniel W.

AU - Willett, Walter C.

AU - Bell, Debra A.

AU - Ng, Won G.

AU - Harlow, Bernard L.

AU - Welch, William R.

AU - Scully, Robert E.

AU - Knapp, Robert C.

N1 - Funding Information: Ms Leslie Fortier, Ms Dawn Harvey, Ms Judy Geller, and Ms Emily Lublin is gratefully acknowledged. This study was supported by grant R01 CA 42008 from the National Cancer Institute.

PY - 1989/7/8

Y1 - 1989/7/8

N2 - In a case-control study, consumption of dairy foods by 235 white women with epithelial ovarian cancer and by 239 control women, and activity of red blood cell galactose-1-phosphate uridyl transferase (transferase) in a subset of 145 cases and 127 controls were determined. Yogurt was consumed at least monthly by 49% of cases and 36% of controls. The mean transferase activity of cases was significantly lower than that of controls. When a ratio of lactose consumption to transferase (L/T) was calculated, cases had a mean L/T of 1·17 compared with 0·98 for controls; there was a highly significant trend for increasing ovarian cancer risk with increasing L/T ratio. Lactose consumption may be a dietary risk factor and transferase a genetic risk factor for ovarian cancer.

AB - In a case-control study, consumption of dairy foods by 235 white women with epithelial ovarian cancer and by 239 control women, and activity of red blood cell galactose-1-phosphate uridyl transferase (transferase) in a subset of 145 cases and 127 controls were determined. Yogurt was consumed at least monthly by 49% of cases and 36% of controls. The mean transferase activity of cases was significantly lower than that of controls. When a ratio of lactose consumption to transferase (L/T) was calculated, cases had a mean L/T of 1·17 compared with 0·98 for controls; there was a highly significant trend for increasing ovarian cancer risk with increasing L/T ratio. Lactose consumption may be a dietary risk factor and transferase a genetic risk factor for ovarian cancer.

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GALACTOSE CONSUMPTION AND METABOLISM IN RELATION TO THE RISK OF OVARIAN CANCER

Abstract

Bibliographical note

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