Galactan induces macrophage M0 to M1 conversion to combat colon cancer

Yue Meng; Guang Yang; Ai Ren; Yunhe Qu; Xue Wang; Kevin H. Mayo; Yifa Zhou; Chengcheng Song

doi:10.3136/fstr.fstr-d-23-00039

Galactan induces macrophage M0 to M1 conversion to combat colon cancer

Yue Meng
, Guang Yang
, Ai Ren
, Yunhe Qu
, Xue Wang
, Kevin H. Mayo
, Yifa Zhou
, Chengcheng Song

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

A 3-O-methylated-galactan WCCP-N-b from Cantharellus cibarius polarizes RAW264.7 macrophages, bone marrow-derived macrophages (BMDMs), and peritoneal macrophages (PEMs) leading to enhanced secretion of cytokine TNF-α and subsequent cytotoxic effects on HCT116 and CT26 colon cancer cells. Investigation into the mechanism of action suggests that WCCP-N-b polarizes macrophages by targeting Toll-like receptor 2 and activation of MAPKs and NF-κB signaling pathways. Overall, our results indicate that this linear 3-O-methylated-galactan inhibits colon cancer cells via conversion of M0 to M1 macrophages.

Original language	English (US)
Pages (from-to)	75-82
Number of pages	8
Journal	Food Science and Technology Research
Volume	30
Issue number	1
DOIs	https://doi.org/10.3136/fstr.fstr-d-23-00039
State	Published - 2024

Bibliographical note

Publisher Copyright:
© 2024 Japanese Society for Food Science and Technology. All rights reserved.

Keywords

antitumor effect
Cantharellus cibarius
galactan
macrophages

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Publisher link

10.3136/fstr.fstr-d-23-00039

https://www.jstage.jst.go.jp/article/fstr/30/1/30_FSTR-D-23-00039/_pdf

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title = "Galactan induces macrophage M0 to M1 conversion to combat colon cancer",

abstract = "A 3-O-methylated-galactan WCCP-N-b from Cantharellus cibarius polarizes RAW264.7 macrophages, bone marrow-derived macrophages (BMDMs), and peritoneal macrophages (PEMs) leading to enhanced secretion of cytokine TNF-α and subsequent cytotoxic effects on HCT116 and CT26 colon cancer cells. Investigation into the mechanism of action suggests that WCCP-N-b polarizes macrophages by targeting Toll-like receptor 2 and activation of MAPKs and NF-κB signaling pathways. Overall, our results indicate that this linear 3-O-methylated-galactan inhibits colon cancer cells via conversion of M0 to M1 macrophages.",

keywords = "antitumor effect, Cantharellus cibarius, galactan, macrophages",

author = "Yue Meng and Guang Yang and Ai Ren and Yunhe Qu and Xue Wang and Mayo, \{Kevin H.\} and Yifa Zhou and Chengcheng Song",

year = "2024",

doi = "10.3136/fstr.fstr-d-23-00039",

language = "English (US)",

volume = "30",

pages = "75--82",

journal = "Food Science and Technology Research",

issn = "1344-6606",

publisher = "Japanese Society for Food Science and Technology",

number = "1",

}

TY - JOUR

T1 - Galactan induces macrophage M0 to M1 conversion to combat colon cancer

AU - Meng, Yue

AU - Yang, Guang

AU - Ren, Ai

AU - Qu, Yunhe

AU - Wang, Xue

AU - Mayo, Kevin H.

AU - Zhou, Yifa

AU - Song, Chengcheng

PY - 2024

Y1 - 2024

N2 - A 3-O-methylated-galactan WCCP-N-b from Cantharellus cibarius polarizes RAW264.7 macrophages, bone marrow-derived macrophages (BMDMs), and peritoneal macrophages (PEMs) leading to enhanced secretion of cytokine TNF-α and subsequent cytotoxic effects on HCT116 and CT26 colon cancer cells. Investigation into the mechanism of action suggests that WCCP-N-b polarizes macrophages by targeting Toll-like receptor 2 and activation of MAPKs and NF-κB signaling pathways. Overall, our results indicate that this linear 3-O-methylated-galactan inhibits colon cancer cells via conversion of M0 to M1 macrophages.

AB - A 3-O-methylated-galactan WCCP-N-b from Cantharellus cibarius polarizes RAW264.7 macrophages, bone marrow-derived macrophages (BMDMs), and peritoneal macrophages (PEMs) leading to enhanced secretion of cytokine TNF-α and subsequent cytotoxic effects on HCT116 and CT26 colon cancer cells. Investigation into the mechanism of action suggests that WCCP-N-b polarizes macrophages by targeting Toll-like receptor 2 and activation of MAPKs and NF-κB signaling pathways. Overall, our results indicate that this linear 3-O-methylated-galactan inhibits colon cancer cells via conversion of M0 to M1 macrophages.

KW - antitumor effect

KW - Cantharellus cibarius

KW - galactan

KW - macrophages

UR - https://www.scopus.com/pages/publications/85184843246

UR - https://www.scopus.com/pages/publications/85184843246#tab=citedBy

U2 - 10.3136/fstr.fstr-d-23-00039

DO - 10.3136/fstr.fstr-d-23-00039

M3 - Article

AN - SCOPUS:85184843246

SN - 1344-6606

VL - 30

SP - 75

EP - 82

JO - Food Science and Technology Research

JF - Food Science and Technology Research

IS - 1

ER -

Galactan induces macrophage M0 to M1 conversion to combat colon cancer

Abstract

Bibliographical note

Keywords

UN SDGs

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