Gaining insight into tablet capping tendency from compaction simulation

Shubhajit Paul, Changquan Calvin Sun

Research output: Contribution to journalArticlepeer-review

51 Scopus citations


Capping or lamination is an unsolved common problem in tablet manufacturing. Knowledge gaps remain despite an enormous amount of effort made in the past to better understand the tablet capping/lamination phenomenon. Using acetaminophen – containing formulations, we examined the potential use of a compaction simulator as a material-sparing tool to predict capping occurrence under commercial tableting conditions. Systematical analyses of the in-die compaction data led to insight on the potential mechanism of tablet capping/lamination. In general, capping strongly correlates with high in-die elastic recovery, high Poisson's ratio, low tensile strength, and radial die-wall pressure. Such insight can be used to guide the formulation design of high quality tablet products that are free from capping problems for challenging active pharmaceutical ingredients.

Original languageEnglish (US)
Pages (from-to)111-120
Number of pages10
JournalInternational journal of pharmaceutics
Issue number1-2
StatePublished - May 30 2017

Bibliographical note

Publisher Copyright:
© 2017 Elsevier B.V.


  • Capping
  • Compaction simulation
  • Formulation development
  • Lamination
  • Mechanical property
  • Tableting


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