Gain-of-Function Properties of a Dynamin 2 Mutant Implicated in Charcot-Marie-Tooth Disease

Keyphrases

• Charcot-Marie-Tooth Disease 100%
• Gain-of-function 100%
• Function Properties 100%
• Dynamin 100%
• Centronuclear Myopathy 72%
• GTPase Signaling 27%
• Self-assembly 9%
• Molecular Mechanism 9%
• Loss Function 9%
• Nerve 9%
• Constriction 9%
• Tyrosine Phosphorylation 9%
• Endocytosis 9%
• Mutant Forms 9%
• Autosomal Dominant 9%
• Cause of Disease 9%
• Disease-causing mutations 9%
• Phosphatidylinositol 4,5-bisphosphate (PIP2) 9%
• Fission 9%
• GTPase 9%
• Intramolecular Interactions 9%
• Pleckstrin Homology Domain 9%
• Motor Disorders 9%

Biochemistry, Genetics and Molecular Biology

• Dynamin 100%
• GTPase 36%
• Wild Type 9%
• Tyrosine Phosphorylation 9%
• Pleckstrin Homology Domain 9%
• Autosomal Dominant Inheritance 9%
• Endocytosis 9%
• Phosphatidylinositol 4,5-bisphosphate 9%