GABA binding in the brains of aggressive and non-aggressive female hamsters

M. Potegal, A. S. Perumal, A. I. Barkai, G. E. Cannova, A. D. Blau

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


Ovariectomized female hamsters were selected for agrressiveness of non-aggressiveness toward a drug-treated target hamster. Animals in the aggressive group were found to have significantly higher levels of GABA binding in their brain 'midregions' (including limbic, striatal and diencephalic structures). There were no between-group GABA binding differences in cortex or pons/medulla and no differences in dihydroalprenolol (DHA) binding in any of these three regions. The groups did not differ on a variety of other behavioral tests including measures of activity, emotionality, feeding, and hormonally primed sexual behavior. The differences in 'midregion' GABA binding therefore may relate to levels of aggressiveness specifically.

Original languageEnglish (US)
Pages (from-to)315-324
Number of pages10
JournalBrain Research
Issue number2
StatePublished - Sep 16 1982
Externally publishedYes

Bibliographical note

Funding Information:
We would like to thank Dr. Ralph Noble for his advice on the design of the lordosis test and Mrs. Ludmila Skaredoff for her assistance at several other stages of this project. This work was supported in part by a grant from the Harry F. Guggenheim Foundation.


  • GABA binding
  • dihydroprenolol binding
  • hamster
  • intraspecific aggression
  • receptors


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