G-protein-coupled receptor regulation of de novo purine biosynthesis: A novel druggable mechanism

Ye Fang, Jarrod French, Hong Zhao, Stephen Benkovic

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Spatial organization of metabolic enzymes may represent a general cellular mechanism to regulate metabolic flux. One recent example of this type of cellular phenomenon is the purinosome, a newly discovered multi-enzyme metabolic assembly that includes all of the enzymes within the de novo purine biosynthetic pathway. Our understanding of the components and regulation of purinosomes has significantly grown in recent years. This paper reviews the purine de novo biosynthesis pathway and its regulation, and presents the evidence supporting the purinosome assembly and disassembly processes under the control of G-protein-coupled receptor (GPCR) signaling. This paper also discusses the implications of purinosome and GPCR regulation in drug discovery.

Original languageEnglish (US)
Pages (from-to)31-48
Number of pages18
JournalBiotechnology and Genetic Engineering Reviews
Volume29
Issue number1
DOIs
StatePublished - 2013
Externally publishedYes

Bibliographical note

Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.

Keywords

  • Drug discovery
  • Dynamic mass redistribution assay
  • G protein-coupled receptor
  • Metabolic flux
  • Mitogenic signaling
  • Purine de novo biosynthesis
  • Purine salvage pathway
  • Purinosome

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