It remains unclear whether ambivalence reflects genetic liability for schizophrenia-spectrum disorders. This study examined whether task-measured ambivalence is 1) increased in schizophrenia/schizoaffective disorder, 2) significantly associated with schizophrenia symptoms, and/or 3) increased in first-degree biological relatives of probands. Consistent with previous research, ambivalence was elevated in schizophrenia/schizoaffective probands and significantly related to current emotional state, but not to symptoms. Ambivalence was not elevated in relatives, suggesting that it may be unrelated to genetic liability. These results suggest that emotional state may differentially influences ambivalence across groups. Future research would benefit from examination of this question in a larger cohort.
|Original language||English (US)|
|Number of pages||3|
|State||Published - 2014|
Bibliographical noteFunding Information:
Dr. Docherty was supported by a National Institute of Mental Health Ruth Kirschstein National Research Award (NRSA)/1F31MH092081 and an American Psychological Foundation F.J. McGuigan Award. This research was also supported by Merit Review grants from the Department of Veterans Affairs Clinical Science Research and Development Program ( 1I01CX000227 ), the National Institute of Mental Health ( 5R24MH069675 ) and the Minnesota Medical Foundation ( SMF-2075-99 ) to Dr. Sponheim, and the Minneapolis VA Health Care System Mental Health Patient Service Line .
- First-degree relatives