Fungal proteinaceous compounds with multiple biological activities

Tzi Bun Ng; Randy Chi Fai Cheung; Jack Ho Wong; Yau Sang Chan; Xiuli Dan; Wenliang Pan; Hexiang Wang; Suzhen Guan; Ki Chan; Xiuyun Ye; Fang Liu; Lixin Xia; Wai Yee Chan

doi:10.1007/s00253-016-7671-9

Fungal proteinaceous compounds with multiple biological activities

Tzi Bun Ng
, Randy Chi Fai Cheung
, Jack Ho Wong
, Yau Sang Chan
, Xiuli Dan
, Wenliang Pan
, Hexiang Wang
, Suzhen Guan
, Ki Chan
, Xiuyun Ye
, Fang Liu
, Lixin Xia
, Wai Yee Chan

Research output: Contribution to journal › Review article › peer-review

19 Scopus citations

Abstract

Fungi comprise organisms like molds, yeasts and mushrooms. They have been used as food or medicine for a long time. A large number of fungal proteins or peptides with diverse biological activities are considered as antibacterial, antifungal, antiviral and anticancer agents. They encompass proteases, ribosome inactivating proteins, defensins, hemolysins, lectins, laccases, ribonucleases, immunomodulatory proteins, and polysaccharopeptides. The target of the present review is to update the status of the various bioactivities of these fungal proteins and peptides and discuss their therapeutic potential.

Original language	English (US)
Pages (from-to)	6601-6617
Number of pages	17
Journal	Applied Microbiology and Biotechnology
Volume	100
Issue number	15
DOIs	https://doi.org/10.1007/s00253-016-7671-9
State	Published - Aug 1 2016
Externally published	Yes

Bibliographical note

Funding Information:
We gratefully acknowledge the award of a Health and Medical Research Fund research grant (no. 12131221 and 12110282) from the Food and Health Bureau, Hong Kong Special Administration Region Government, research grants from the National Natural Science Foundation of China (no. 81201270 and 81471927) and direct grants 4054049 and 4054135 from the Medicine Panel, Research Committee, of the Chinese University of Hong Kong.

Publisher Copyright:
© 2016, Springer-Verlag Berlin Heidelberg.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Antibacterial
Anticancer
Antifungal
Antiviral
Fungi
Proteins

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10.1007/s00253-016-7671-9

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abstract = "Fungi comprise organisms like molds, yeasts and mushrooms. They have been used as food or medicine for a long time. A large number of fungal proteins or peptides with diverse biological activities are considered as antibacterial, antifungal, antiviral and anticancer agents. They encompass proteases, ribosome inactivating proteins, defensins, hemolysins, lectins, laccases, ribonucleases, immunomodulatory proteins, and polysaccharopeptides. The target of the present review is to update the status of the various bioactivities of these fungal proteins and peptides and discuss their therapeutic potential.",

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note = "Funding Information: We gratefully acknowledge the award of a Health and Medical Research Fund research grant (no. 12131221 and 12110282) from the Food and Health Bureau, Hong Kong Special Administration Region Government, research grants from the National Natural Science Foundation of China (no. 81201270 and 81471927) and direct grants 4054049 and 4054135 from the Medicine Panel, Research Committee, of the Chinese University of Hong Kong. Publisher Copyright: {\textcopyright} 2016, Springer-Verlag Berlin Heidelberg.",

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doi = "10.1007/s00253-016-7671-9",

language = "English (US)",

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T1 - Fungal proteinaceous compounds with multiple biological activities

AU - Ng, Tzi Bun

AU - Cheung, Randy Chi Fai

AU - Wong, Jack Ho

AU - Chan, Yau Sang

AU - Dan, Xiuli

AU - Pan, Wenliang

AU - Wang, Hexiang

AU - Guan, Suzhen

AU - Chan, Ki

AU - Ye, Xiuyun

AU - Liu, Fang

AU - Xia, Lixin

AU - Chan, Wai Yee

N1 - Funding Information: We gratefully acknowledge the award of a Health and Medical Research Fund research grant (no. 12131221 and 12110282) from the Food and Health Bureau, Hong Kong Special Administration Region Government, research grants from the National Natural Science Foundation of China (no. 81201270 and 81471927) and direct grants 4054049 and 4054135 from the Medicine Panel, Research Committee, of the Chinese University of Hong Kong. Publisher Copyright: © 2016, Springer-Verlag Berlin Heidelberg.

PY - 2016/8/1

Y1 - 2016/8/1

N2 - Fungi comprise organisms like molds, yeasts and mushrooms. They have been used as food or medicine for a long time. A large number of fungal proteins or peptides with diverse biological activities are considered as antibacterial, antifungal, antiviral and anticancer agents. They encompass proteases, ribosome inactivating proteins, defensins, hemolysins, lectins, laccases, ribonucleases, immunomodulatory proteins, and polysaccharopeptides. The target of the present review is to update the status of the various bioactivities of these fungal proteins and peptides and discuss their therapeutic potential.

AB - Fungi comprise organisms like molds, yeasts and mushrooms. They have been used as food or medicine for a long time. A large number of fungal proteins or peptides with diverse biological activities are considered as antibacterial, antifungal, antiviral and anticancer agents. They encompass proteases, ribosome inactivating proteins, defensins, hemolysins, lectins, laccases, ribonucleases, immunomodulatory proteins, and polysaccharopeptides. The target of the present review is to update the status of the various bioactivities of these fungal proteins and peptides and discuss their therapeutic potential.

KW - Antibacterial

KW - Anticancer

KW - Antifungal

KW - Antiviral

KW - Fungi

KW - Proteins

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UR - https://www.scopus.com/pages/publications/84976322368#tab=citedBy

U2 - 10.1007/s00253-016-7671-9

DO - 10.1007/s00253-016-7671-9

M3 - Review article

C2 - 27338574

AN - SCOPUS:84976322368

SN - 0175-7598

VL - 100

SP - 6601

EP - 6617

JO - Applied Microbiology and Biotechnology

JF - Applied Microbiology and Biotechnology

IS - 15

ER -

Fungal proteinaceous compounds with multiple biological activities

Abstract

Bibliographical note

UN SDGs

Keywords

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