Fungal innate immunity induced by bacterial microbe-associated molecular patterns (MAMPs)

Simon Ipcho, Thomas Sundelin, Gitte Erbs, H. Corby Kistler, Mari Anne Newman, Stefan Olsson

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Plants and animals detect bacterial presence through Microbe-Associated Molecular Patterns (MAMPs) which induce an innate immune response. The field of fungal-bacterial interaction at the molecular level is still in its infancy and little is known about MAMPs and their detection by fungi. Exposing Fusarium graminearum to bacterial MAMPs led to increased fungal membrane hyperpolarization, a putative defense response, and a range of transcriptional responses. The fungus reacted with a different transcript profile to each of the three tested MAMPs, although a core set of genes related to energy generation, transport, amino acid production, secondary metabolism, and especially iron uptake were detected for all three. Half of the genes related to iron uptake were predicted MirA type transporters that potentially take up bacterial siderophores. These quick responses can be viewed as a preparation for further interactions with beneficial or pathogenic bacteria, and constitute a fungal innate immune response with similarities to those of plants and animals.

Original languageEnglish (US)
Pages (from-to)1585-1595
Number of pages11
JournalG3: Genes, Genomes, Genetics
Volume6
Issue number6
DOIs
StatePublished - 2016

Keywords

  • Fungal-bacterial interaction
  • Innate immunity
  • MAMPs
  • Transcriptomics

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