Functionalization of polymer multilayer thin films for novel biomedical applications

Yeongseon Jang, Saibom Park, Kookheon Char

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations


The design of functional polymer multilayer thin films with nanometer scale control is of great interest for biomedical applications such as tissue engineering, targeted drug delivery, controlled release system, and regenerative medicine. Various functions and properties of polymer thin films can be easily programmed and realized by the layer-by-layer assembly strategy, which is a facile and versatile deposition method to prepare well-defined biomedical multilayer platforms due to its benign process to prepare films under mild conditions and the capability of incorporating bioactive materials at a desired location within the films. Particularly, the fine tuning of physicochemical and biological properties of multilayer thin films is significantly important for designing novel biomedical platforms capable of adjusting the cellular functions. In this review, we focus on the overall background of the layer-by-layer assembly as well as the tuning of multilayer film properties and the programming of biological functions into the polymer thin films with a view on the control of cellular functions. Furthermore, we highlighted the recent achievements toward the design of novel biomedical platforms based on functionalized polymer multilayer thin films.

Original languageEnglish (US)
Pages (from-to)1149-1160
Number of pages12
JournalKorean Journal of Chemical Engineering
Issue number5
StatePublished - May 2011
Externally publishedYes

Bibliographical note

Funding Information:
This work was financially supported by the National Research Foundation of Korea (NRF) funded by the Korea Ministry of Education, Science, and Technology (MEST) (The Creative Research Initiative Program for “Intelligent Hybrids Research Center” (No. 2010-0018290)), The NANO Systems Institute National Core Research Center (R15-2003-032-02002-0), The WCU C2E2 Program (R31-10013), and BK21 Chemical Engineering Program funded by the Ministry of Education, Science and Technology (MEST).


  • Bio-functionalization
  • Biomedical Platform(s)
  • Cellular Function(s)
  • Layer-by-layer Assembly
  • Multilayer Thin Film(s)


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