Functional specialization of mouse higher visual cortical areas

Mark L. Andermann, Aaron M. Kerlin, Demetris K. Roumis, Lindsey L. Glickfeld, R. Clay Reid

Research output: Contribution to journalArticle

206 Scopus citations

Abstract

The mouse is emerging as an important model for understanding how sensory neocortex extracts cues to guide behavior, yet little is known about how these cues are processed beyond primary cortical areas. Here, we used two-photon calcium imaging in awake mice to compare visual responses in primary visual cortex (V1) and in two downstream target areas, AL and PM. Neighboring V1 neurons had diverse stimulus preferences spanning five octaves in spatial and temporal frequency. By contrast, AL and PM neurons responded best to distinct ranges of stimulus parameters. Most strikingly, AL neurons preferred fast-moving stimuli while PM neurons preferred slow-moving stimuli. By contrast, neurons in V1, AL, and PM demonstrated similar selectivity for stimulus orientation but not for stimulus direction. Based on these findings, we predict that area AL helps guide behaviors involving fast-moving stimuli (e.g., optic flow), while area PM helps guide behaviors involving slow-moving objects.

Original languageEnglish (US)
Pages (from-to)1025-1039
Number of pages15
JournalNeuron
Volume72
Issue number6
DOIs
StatePublished - Dec 22 2011
Externally publishedYes

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    Andermann, M. L., Kerlin, A. M., Roumis, D. K., Glickfeld, L. L., & Reid, R. C. (2011). Functional specialization of mouse higher visual cortical areas. Neuron, 72(6), 1025-1039. https://doi.org/10.1016/j.neuron.2011.11.013